Kevin Matthew McKay Week 5
From OpenWetWare
Genes
- GDH1
- Expression is regulated by carbon sources
- High expression in presence of glucose and ethanol
- Expression is regulated by carbon sources
- GDH3
- Expression regulated by carbon sources
- High expression in presence of ethanol, repressed by glucose
- Expression regulated by carbon sources
- GDH2
- Homo Sapien Homolog:
- GLUD2 and GLUD1
- Deficiency has been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders.
- GLUD2 and GLUD1
- Expression regulated by nitrogen catabolite repression and intracellular ammonia levels
- Also regulated through transcription in the promoter
- Homo Sapien Homolog:
- GLN1
- Expression regulated by nitrogen source and amino acid limitation
- GLT1
- Expression regulated by glutamate-mediated repression and GLN3P/GCN4P-mediated activation, availability of nitrogen and glutamate, and when amino acids are limiting, GLT1 expression is activated by GCN4P.
- Parameters related to our chemostat model were found in many of the papers related to these five genes including amounts of nutrients carbon and nitrogen (carbon being held constant in the ter shure paper), flux rate, (which was also held constant in the ter shure paper).
- L-GLutamate is involved in 56 pathways
- [- glutamate pathway]