Kevin Matthew McKay Week 5: Difference between revisions
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*[[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=4&detail-level=3 - glutamate pathway]] | *[[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=4&detail-level=3 - glutamate pathway]] | ||
*[[Image:Screen Shot 2013-02-13 at 5.42.55 PM.png|Screenshot]] | *[[Image:Screen Shot 2013-02-13 at 5.42.55 PM.png|Screenshot]] | ||
==KEGG Pathway== | |||
*[[Image:Screen Shot 2013-02-13 at 9.32.51 PM.png|Central Nitrogen Metabolism]] | |||
*All pf the genes in the reference pathway are in the yeast pathway on the website | |||
*The KEGG website gave the amino acid and nucleotide sequences of the genes while the other website did not | |||
[[Category:BIOL398-03/S13]] | [[Category:BIOL398-03/S13]] |
Revision as of 22:45, 13 February 2013
Genes
- GDH1
- 2 Homo sapien Homologues:
- 1NR1 and 1L1F
- Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
- 1NR1 and 1L1F
- Expression is regulated by carbon sources
- High expression in presence of glucose and ethanol
- 2 Homo sapien Homologues:
- GDH3
- 2 Homo sapien Homologues:
- 1NR1 and 1L1F
- Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
- 1NR1 and 1L1F
- Expression regulated by carbon sources
- High expression in presence of ethanol, repressed by glucose
- 2 Homo sapien Homologues:
- GDH2
- Homo Sapien Homolog:
- GLUD2
- Deficiency causes hyperinsulinism
- GLUD2
- Expression regulated by nitrogen catabolite repression and intracellular ammonia levels
- Homo Sapien Homolog:
- GLN1
- Homo sapien homologues:
- 2OJW and 2QC8
- Changes in activity of these genes has been linked to Alzheimer's disease
- Expression regulated by nitrogen source and amino acid limitation
- GLT1
- No Homo sapien homolog
- Expression regulated by glutamate-mediated repression and GLN3P/GCN4P-mediated activation, availability of nitrogen and glutamate, and when amino acids are limiting, GLT1 expression is activated by GCN4P.
- L-GLutamate is involved in 56 pathways
- [- glutamate pathway]