Kathleen McGinness

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==Education/Work Experience==
 
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*Postdoc in the [http://web.mit.edu/biology/sauerlab/ Sauer Lab] at [http://web.mit.edu/ MIT]
 
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*Ph.D. in Chemistry, [http://www.scripps.edu/e_index.html The Scripps Research Institute], 2001 (with [http://www.scripps.edu/mb/joyce/joycelab.html Gerald Joyce])
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*Postdoc in the [http://mit.edu/sauerlab/ Sauer lab] at [http://web.mit.edu/ MIT] (2001–2006)
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**[[Sauer Lab|Sauer lab OWW page]]
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*B.S. in Chemistry, [http://www.umd.edu University of Maryland College Park], 1996
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==Fun facts==
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*B.S. in Psychology, University of Maryland College Park, 1996
 
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*'''Who's visiting?'''
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== Science stuff I know something about... ==
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<html>
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<a href="http://clustrmaps.com/counter/maps.php?url=http://openwetware.org/wiki/Kathleen_McGinness" id="clustrMapsLink"><img src="http://clustrmaps.com/counter/index2.php?url=http://openwetware.org/wiki/Kathleen_McGinness" border=1 alt="Locations of visitors to this page"onError="this.onError=null; this.src='http://www.meetomatic.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://clustrmaps.com/'">
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</a>
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</html>
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*tmRNA (or SsrA/10Sa RNA for you purists)
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*Here is an excellent tutorial on how [http://video.google.com/videoplay?docid=-2657697036715872139 translation] works, with an introduction by the 1971 version of nobel laureate [http://nobelprize.org/chemistry/laureates/1980/berg-cv.html Paul Berg]. I'd like to see it in classrooms everywhere. '''tRNA! peptide bond!'''
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*translation
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*energy-dependent proteolysis in bacteria
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*The RNA World
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*molecular biology in a world without kits
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*''in vitro'' selection and evolution of nucleic acids
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*generation of nucleic acid and protein libraries
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*''in vitro'' RNA techniques
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*nucleic acid-protein interactions
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*fishing experiments to look for things that interact with your RNA/DNA/protein of interest
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*PCR (even colony PCR, although it is '''not''' a separate skill)
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*bacterial protein expression/purification
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*''in vivo'' assays with ''E. coli'' i.e. analyzing effects on proteins/RNA
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*molecular cloning
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*Western/Northern/Southern blot analysis
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*oligonucleotide synthesis
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*RNA/DNA sequencing
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*structural probing of RNA/DNA
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*gels, all kinds of gels: agarose, native acrylamide,  denaturing acrylamide, SDS-acrylamide, two-dimensional
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*enzyme kinetics
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*radiolabeling nucleic acids and proteins
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=Publications=
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'''[http://www.pnas.org/cgi/content/full/101/37/13454 Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.]'''
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McGinness, K.E. & Sauer, R.T. (2004) Proc. Natl. Acad. Sci. USA 101, 13454–13459.
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'''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12677051&query_hl=1 A Glimpse into tmRNA-mediated Ribosome Rescue.]'''
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Moore, S.D., McGinness, K.E. & Sauer, R.T. (2003)  Science 300, 127–130. (comment)
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'''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12573693&query_hl=1 In Search of an RNA Replicase Ribozyme.]'''
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McGinness, K.E. & Joyce, G.F. (2003)  Chem. Biol. 10, 5–14. (review)
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'''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12031665&query_hl=1 Continuous In Vitro Evolution of a Ribozyme that Catalyzes Three Successive Nucleotidyl Addition Reactions.]'''
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McGinness, K.E., Wright, M.C. & Joyce, G.F. (2002)  Chem. Biol. 9, 585–596.
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'''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11927255&query_hl=1 RNA-Catalyzed RNA Ligation on an External RNA Template.]'''
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McGinness, K.E. & Joyce, G.F. (2002)  Chem. Biol. 9, 297–307.
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'''[http://www.jbc.org/cgi/content/full/277/4/2987 Substitution of Ribonucleotides in the T7 RNA Polymerase Promoter Element.]'''
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McGinness, K.E. & Joyce, G.F. (2002)  J. Biol. Chem. 277, 2987–2991.
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[[KM:Personal|<font size=4>"Personal"</font>]]
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=="Personal"==
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===Bio===
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I'm a fourth (at least!) generation Marylander who grew up in the happy Washington, D.C. suburb of Derwood. I began my college career majoring in Biology at [http://www.psu.edu/ Penn State], but after realizing that the bustling metropolis of State College was not for me, I transferred to the University of Maryland. When I started at Maryland, I realized that although I support the need for animal research, I don't have the stomach for it. So, I decided to change my major to Chemistry, and threw in a major in Psychology for good measure. While at Maryland, I had the opportunity to work in the Laboratory of Neurochemistry and the Laboratory of General and Comparative Biochemistry at [http://www.nimh.nih.gov/ NIMH] (yes, where the rats are from).  I also got my first introduction into the RNA world by working in [http://biophysics.jhu.edu/faculty-pages/woodson.html Sarah Woodson's lab] while she was at Maryland. After four years (yes, that makes it a 5 year plan for college!), I packed up my worldly possessions and headed to sunny So. Cal. to do my graduate work at Scripps with Jerry Joyce, solidifying my love of the RNA world. Much like [[user:skosuri|Sr]]i, I fell in love with CA. So, after completing my Ph.D. in chemistry (biochemistry, really), I returned to the east coast to work at MIT. In Bob Sauer's lab I have expanded my science into the protein world, but I'm still an RNA girl at heart. When I get the time, I'll put up some of my current research here.
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===Random Stuff===
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*My new favorite website detailing an alternative theory to evolution ([http://www.venganza.org/ WWFSMD?]).
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*Lab-related pet peeves (partial list...)
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**beeping timers
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**people from other labs that come in asking for something and don't introduce themselves first (is it so hard to say,"Hi, I'm <insert name here> from the <insert PI name here> lab"??)
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*I have the messiest bench (and desk) in the lab. Paradoxically, I am a tyrant about cleanliness in common lab areas.
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*[[KM's soapbox]]
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[[Sauer Lab| Back to the Sauer lab]]
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Current revision

Fun facts

  • Who's visiting?

Locations of visitors to this page

  • Here is an excellent tutorial on how translation works, with an introduction by the 1971 version of nobel laureate Paul Berg. I'd like to see it in classrooms everywhere. tRNA! peptide bond!
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