Josh Michener - Revision history

Josh K. Michener at 17:59, 25 March 2013

Josh K. Michener — Mon, 25 Mar 2013 17:59:17 GMT

←Older revision		Revision as of 17:59, 25 March 2013
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	==Lab history==		==Lab history==
-	*~~Postdoc~~ in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology	+	*NRSA Postdoctoral Fellow in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
	*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)		*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
	*UROP in the Endy Lab at MIT		*UROP in the Endy Lab at MIT

Josh K. Michener at 22:01, 20 November 2012

Josh K. Michener — Tue, 20 Nov 2012 22:01:23 GMT

←Older revision		Revision as of 22:01, 20 November 2012
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	==Publications==		==Publications==
-	*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ~~''In Press''~~ [http://www.pnas.org/content/~~early/2012/10~~/31/~~1212287109~~.abstract]	+	*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. 2012; 109 (47) 19504-19509. [http://www.pnas.org/content/109/47/19504.abstract]
-	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]	+	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul; 14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
-	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]	+	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May; 14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]

Josh K. Michener at 02:50, 6 November 2012

Josh K. Michener — Tue, 06 Nov 2012 02:50:12 GMT

←Older revision		Revision as of 02:50, 6 November 2012
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	==Publications==		==Publications==
-	*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ''In Press''	+	*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ''In Press'' [http://www.pnas.org/content/early/2012/10/31/1212287109.abstract]
	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]		*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]		*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]

Josh K. Michener at 01:29, 10 October 2012

Josh K. Michener — Wed, 10 Oct 2012 01:29:35 GMT

←Older revision		Revision as of 01:29, 10 October 2012
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	==Contact Info==		==Contact Info==
	Josh Michener<br>		Josh Michener<br>
-	~~Bioengineering - Smolke Lab~~<br>	+	16 Divinity Ave Room 3082<br>
-	~~Y2E2-B07~~, ~~MC 4200<br>~~	+	Cambridge, MA, 02138<br>
-	~~473 Via Ortega<br>~~	+
-	~~Stanford~~, ~~CA 94305~~<br>	+

	[[Image:Michener-email.png]]		[[Image:Michener-email.png]]
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	==Publications==		==Publications==
-	*'''Michener JK'', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ''In Press''	+	*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ''In Press''
	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]		*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]		*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]

Josh K. Michener at 01:27, 10 October 2012

Josh K. Michener — Wed, 10 Oct 2012 01:27:34 GMT

←Older revision		Revision as of 01:27, 10 October 2012
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	==Publications==		==Publications==
		+	*'''Michener JK'', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. ''In Press''
	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]		*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]		*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]

Josh K. Michener at 00:27, 14 August 2012

Josh K. Michener — Tue, 14 Aug 2012 00:27:24 GMT

←Older revision		Revision as of 00:27, 14 August 2012
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	==Lab history==		==Lab history==
	*Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology		*Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
-	*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. ~~Co-advised by~~ Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)	+	*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
	*UROP in the Endy Lab at MIT		*UROP in the Endy Lab at MIT

Josh K. Michener at 00:56, 22 June 2012

Josh K. Michener — Fri, 22 Jun 2012 00:56:05 GMT

←Older revision		Revision as of 00:56, 22 June 2012
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		+	{\|cellspacing="5" cellpadding="10" style="background:#151B54; width: 750px;"
		+	\|-valign="top"
		+	\|style="background:#ffffff"\|
	__NOTOC__		__NOTOC__
	=Josh Michener=		=Josh Michener=

Josh K. Michener at 00:53, 22 June 2012

Josh K. Michener — Fri, 22 Jun 2012 00:53:41 GMT

←Older revision		Revision as of 00:53, 22 June 2012
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-	~~{{Smolke_Top}}~~
	__NOTOC__		__NOTOC__
	=Josh Michener=		=Josh Michener=
	==Education==		==Education==
	[[Image:JKMpic.jpg\|right\|thumb]]		[[Image:JKMpic.jpg\|right\|thumb]]
-	*~~5th year~~ Bioengineering ~~PhD candidate~~ at Caltech	+	*PhD, 2012, Bioengineering at Caltech
-	**On detached duty from Caltech to work at Stanford (January 2009 - Current)	+
-	**Also on detached duty from Stanford to work at the Chalmers Institute of Technology (August 2011 - Current)	+
	*S.B. 2006, Chemical Engineering and Biology at MIT		*S.B. 2006, Chemical Engineering and Biology at MIT

	==Lab history==		==Lab history==
-	*~~Grad~~ student in the [[Smolke]] Lab ~~([http://bioengineering.stanford.edu~~/ Stanford Bioengineering~~]) and [[~~Arnold~~]] Lab~~ (~~[http://be.caltech.edu~~ Caltech ~~Bioengineering]~~).	+	*Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
-	*Rotated in the Smolke, Arnold, and ~~Elowitz labs at Caltech~~	+	*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Co-advised by Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
-	*UROP in the [[Endy Lab]] at ~~[http://web.mit.edu/~~ MIT~~], January 2005 - January 2006.~~	+	*UROP in the Endy Lab at MIT

	==Contact Info==		==Contact Info==
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	==Research==		==Research==
-	My research focuses on ~~applying RNA switches, developed elsewhere in~~ the ~~lab, to provide dynamic control~~ of ~~enzymatic pathways. Specifically, I am using those switches~~ to ~~construct feedback control systems~~, ~~with the goal of producing a predictable output despite variations in reaction conditions. These control systems can then be used in~~ metabolic ~~engineering to change both the transient and equilibrium responses of a pathway~~.	+	My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.

-	==~~Past Projects~~==	+	==Publications==
-	*~~Development of an~~ ''in ~~vivo~~'' ~~screen for~~ synthetic ~~riboswitches~~.	+	*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
-	*Design and construction of a [[Endy:~~Screening plasmid\|screening plasmid]] to measure the PoPS transfer curve of a~~ [http://~~parts~~.~~mit~~.~~edu BioBricks] device.~~	+	*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]
-		+
-	~~==Interesting papers==~~	+
-	*[[User:Jkm/~~Feedback\|Metabolic control]]~~	+
-	*[[User:Jkm/~~Caffeine\|Caffeine metabolism]~~]	+
-		+
-	~~==Random pages==~~	+
-	*~~[http://dx~~.~~doi~~.~~org/10~~.~~1016/S0009-2509~~(03)~~00183~~-~~0d53c2e392aa18 Chemical and Biological Engineering]~~	+
-	*[http://brodylab.~~eng.uci.edu/~jpbrody/reynolds/lowpurcell.html Edward Purcell: Life at Low Reynold's Number]~~	+
-	*[http://www.cs.~~virginia.edu~~/~~~robins~~/~~YouAndYourResearch.html Richard Hamming: You and Your Research]~~	+
-	*[[User:Jkm/~~Alternate_protocols\|Alternate page design]]~~	+
-	*[[User:Jkm/~~sidebar\|My sidebar]]~~	+
-	*[[User:Jkm/What not to do\|Cautionary tales]]	+

Josh K. Michener at 10:58, 11 August 2011

Josh K. Michener — Thu, 11 Aug 2011 10:58:24 GMT

←Older revision		Revision as of 10:58, 11 August 2011
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	[[Image:JKMpic.jpg\|right\|thumb]]		[[Image:JKMpic.jpg\|right\|thumb]]
	*5th year Bioengineering PhD candidate at Caltech		*5th year Bioengineering PhD candidate at Caltech
-	**~~Currently on~~ detached duty at Stanford	+	**On detached duty from Caltech to work at Stanford (January 2009 - Current)
		+	**Also on detached duty from Stanford to work at the Chalmers Institute of Technology (August 2011 - Current)
	*S.B. 2006, Chemical Engineering and Biology at MIT		*S.B. 2006, Chemical Engineering and Biology at MIT

Josh K. Michener at 22:36, 19 October 2010

Josh K. Michener — Tue, 19 Oct 2010 22:36:13 GMT

←Older revision		Revision as of 22:36, 19 October 2010
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	==Education==		==Education==
	[[Image:JKMpic.jpg\|right\|thumb]]		[[Image:JKMpic.jpg\|right\|thumb]]
-	*~~4th~~ year Bioengineering PhD candidate at Caltech	+	*5th year Bioengineering PhD candidate at Caltech
	**Currently on detached duty at Stanford		**Currently on detached duty at Stanford
	*S.B. 2006, Chemical Engineering and Biology at MIT		*S.B. 2006, Chemical Engineering and Biology at MIT