Josh Michener: Difference between revisions
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==Research Experience== | ==Research Experience== | ||
*NRSA Postdoctoral Fellow in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology | *NRSA Postdoctoral Fellow in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology | ||
*Nordic Research | *Nordic Research Fellow in the Nielsen Lab, Chalmers Institute of Technology (Gothenburg, Sweden) | ||
*NSF Predoctoral Fellow in the Smolke Lab, Caltech/Stanford Bioengineering | *NSF Predoctoral Fellow in the Smolke Lab, Caltech/Stanford Bioengineering | ||
*UROP in the Endy Lab at MIT | *UROP in the Endy Lab at MIT |
Revision as of 06:55, 21 March 2014
Josh MichenerEducation
Research Experience
Contact InfoJosh Michener Research InterestsNo gene exists in isolation. To be useful, a gene must be functionally expressed and its host must be able to deal with any resulting stresses. Most genes have had sufficient time in their current host that the gene and host have co-evolved to minimize deleterious interactions. However, while this type of coexistence might be the rule, the exceptions can be both interesting and extremely consequential. When, for example, a microbe acquires new genetic material through horizontal gene transfer or synthetic biology, genes must function in an environment with which they did not co-evolve. Efficient use of a new ability will require careful integration into the existing metabolic and regulatory networks of the host. The interactions between gene and host, as well as their evolutionary outcomes, will determine whether a microbe can become pathogenic, remediate a polluted site, or produce a biofuel. Understanding these interactions and the strategies by which evolution optimizes them will allow us to better anticipate the emergence of new microbial phenotypes. PublicationsResearch Articles
Methods and Reviews
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