Josh Michener

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__NOTOC__
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=Josh Michener=
=Josh Michener=
==Education==
==Education==
[[Image:JKMpic.jpg|right|thumb]]
[[Image:JKMpic.jpg|right|thumb]]
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*1st year Bioengineering grad student at Caltech
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*PhD, 2012, Bioengineering at Caltech
*S.B. 2006, Chemical Engineering and Biology at MIT
*S.B. 2006, Chemical Engineering and Biology at MIT
==Lab history==
==Lab history==
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*Grad student in the [[Smolke Lab]] at [http://www.caltech.edu Caltech].
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*Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
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*Rotated in the Smolke, Arnold, and Elowitz labs at Caltech
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*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
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*UROP in the [[Endy Lab]] at [http://web.mit.edu/ MIT], January 2005 - January 2006.
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*UROP in the Endy Lab at MIT
==Contact Info==
==Contact Info==
Josh Michener<br>
Josh Michener<br>
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1200 E. California Blvd.<br>
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16 Divinity Ave Room 3082<br>
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MC 138-78<br>
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Cambridge, MA, 02138<br>
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Pasadena, CA, 91125<br>
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[[Image:Michener-email.png]]
[[Image:Michener-email.png]]
==Research==
==Research==
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My research focuses on applying RNA switches, developed elsewhere in the lab, to provide dynamic control of enzymatic pathways. Specifically, I am using those switches to construct feedback control systems, with the goal of producing a predictable output despite variations in reaction conditions. These control systems can then be used in metabolic engineering to change both the transient and equilibrium responses of a pathway.
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My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.
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==Past Projects==
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*Development of an ''in vivo'' screen for synthetic riboswitches.
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*Design and construction of a [[Endy:Screening plasmid|screening plasmid]] to measure the PoPS transfer curve of a [http://parts.mit.edu BioBricks] device.
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==Interesting papers==
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*[[User:Jkm/Feedback|Metabolic control]]
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*[[User:Jkm/Caffeine|Caffeine metabolism]]
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==Random pages==
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==Publications==
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*[http://brodylab.eng.uci.edu/~jpbrody/reynolds/lowpurcell.html Edward Purcell: Life at Low Reynold's Number]
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*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. 2012; 109 (47) 19504-19509. [http://www.pnas.org/content/109/47/19504.abstract]
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*[http://www.cs.virginia.edu/~robins/YouAndYourResearch.html Richard Hamming: You and Your Research]
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*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul; 14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
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*[[User:Jkm/Alternate_protocols|Alternate page design]]
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*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May; 14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]
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*[[User:Jkm/sidebar|My sidebar]]
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*[[User:Jkm/What not to do|Cautionary tales]]
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Revision as of 17:01, 20 November 2012

Josh Michener

Education

  • PhD, 2012, Bioengineering at Caltech
  • S.B. 2006, Chemical Engineering and Biology at MIT

Lab history

  • Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
  • Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
  • UROP in the Endy Lab at MIT

Contact Info

Josh Michener
16 Divinity Ave Room 3082
Cambridge, MA, 02138

Image:Michener-email.png

Research

My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.

Publications

  • Michener JK, Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. 2012; 109 (47) 19504-19509. [1]
  • Michener JK and Smolke CD. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng. 2012 Jul; 14(4):306-16. [2]
  • Michener JK, Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May; 14(3):212-22. [3]
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