Josh Michener: Difference between revisions

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{{Smolke_Top}}
__NOTOC__
__NOTOC__
=Josh Michener=
=Josh Michener=
==Education==
==Education==
[[Image:JKMpic.jpg|right|thumb]]
[[Image:JKMpic.jpg|right|thumb]]
*5th year Bioengineering PhD candidate at Caltech
*PhD, 2012, Bioengineering at Caltech
**On detached duty from Caltech to work at Stanford (January 2009 - Current)
**Also on detached duty from Stanford to work at the Chalmers Institute of Technology (August 2011 - Current)
*S.B. 2006, Chemical Engineering and Biology at MIT
*S.B. 2006, Chemical Engineering and Biology at MIT


==Lab history==
==Lab history==
*Grad student in the [[Smolke]] Lab ([http://bioengineering.stanford.edu/ Stanford Bioengineering]) and [[Arnold]] Lab ([http://be.caltech.edu Caltech Bioengineering]).
*Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
*Rotated in the Smolke, Arnold, and Elowitz labs at Caltech
*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Co-advised by Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
*UROP in the [[Endy Lab]] at [http://web.mit.edu/ MIT], January 2005 - January 2006.
*UROP in the Endy Lab at MIT


==Contact Info==
==Contact Info==
Line 24: Line 21:


==Research==
==Research==
My research focuses on applying RNA switches, developed elsewhere in the lab, to provide dynamic control of enzymatic pathways. Specifically, I am using those switches to construct feedback control systems, with the goal of producing a predictable output despite variations in reaction conditions. These control systems can then be used in metabolic engineering to change both the transient and equilibrium responses of a pathway.
My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.


==Past Projects==
==Publications==
*Development of an ''in vivo'' screen for synthetic riboswitches.
*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
*Design and construction of a [[Endy:Screening plasmid|screening plasmid]] to measure the PoPS transfer curve of a [http://parts.mit.edu BioBricks] device.
*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]
 
==Interesting papers==
*[[User:Jkm/Feedback|Metabolic control]]
*[[User:Jkm/Caffeine|Caffeine metabolism]]
 
==Random pages==
*[http://dx.doi.org/10.1016/S0009-2509(03)00183-0d53c2e392aa18 Chemical and Biological Engineering]
*[http://brodylab.eng.uci.edu/~jpbrody/reynolds/lowpurcell.html Edward Purcell: Life at Low Reynold's Number]
*[http://www.cs.virginia.edu/~robins/YouAndYourResearch.html Richard Hamming: You and Your Research]
*[[User:Jkm/Alternate_protocols|Alternate page design]]
*[[User:Jkm/sidebar|My sidebar]]
*[[User:Jkm/What not to do|Cautionary tales]]

Revision as of 17:53, 21 June 2012

Josh Michener

Education

  • PhD, 2012, Bioengineering at Caltech
  • S.B. 2006, Chemical Engineering and Biology at MIT

Lab history

  • Postdoc in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
  • Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Co-advised by Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
  • UROP in the Endy Lab at MIT

Contact Info

Josh Michener
Bioengineering - Smolke Lab
Y2E2-B07, MC 4200
473 Via Ortega
Stanford, CA 94305

Research

My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.

Publications

  • Michener JK and Smolke CD. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng. 2012 Jul;14(4):306-16. [1]
  • Michener JK, Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May;14(3):212-22. [2]
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