James P. McDonald Week 5

Exploring Pathway Databases

Saccharomyces Genome Database

• GDH2 has a homolog in humans. A deficiency of the human homologs, GLUD1 and GLUD2, has been known to cause hyperinsulinism-hyperammonemia syndrome and various neurological disorders.
• Gene Expression Regulation:
  • GDH1: expression regulated by nitrogen and carbon sources
  • GDH3: expression regulated by nitrogen and carbon sources
  • GDH2: expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
  • GLN1: expression regulated by nitrogen source and amino acid limitation
  • GLT1: expression regulated by nitrogen source
• There are 56 pathways listed in the database that L-glutamate participates
• Pathway
  • SGD Pathway
  • 

KEGG

• KEG Pathway
• 

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