James P. McDonald Week 5
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Exploring Pathway Databases
Saccharomyces Genome Database
- GDH2 has a homolog in humans. A deficiency of the human homologs, GLUD1 and GLUD2, has been known to cause hyperinsulinism-hyperammonemia syndrome and various neurological disorders.
- Gene Expression Regulation:
- GDH1: expression regulated by nitrogen and carbon sources
- GDH3: expression regulated by nitrogen and carbon sources
- GDH2: expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
- GLN1: expression regulated by nitrogen source and amino acid limitation
- GLT1: expression regulated by nitrogen source
- There are 56 pathways listed in the database that L-glutamate participates in
- Pathway:
KEGG
- KEG Pathway
- The information provided in KEGG is similar to SGD but KEGG includes 3-D structures of the enzymes and AA and NT sequences.
Reactome
Class Links
- James P. McDonald
- BIOL 398 Home Page
- Week 1 Assignment
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Journal Entries and Assignments
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- James P. McDonald Week 2
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- James P. McDonald Week 5
- James P. McDonald Week 6
- James P. McDonald Week 8
- James P. McDonald Week 9
- James P. McDonald Week 11
- James P. McDonald Week 12
- James P. McDonald Week 13
- James P. McDonald Week 14
