James P. McDonald Week 5: Difference between revisions

Latest revision as of 19:20, 14 February 2013

GDH2 has a homolog in humans. A deficiency of the human homologs, GLUD1 and GLUD2, has been known to cause hyperinsulinism-hyperammonemia syndrome and various neurological disorders.
Gene Expression Regulation:
- GDH1: expression regulated by nitrogen and carbon sources
- GDH3: expression regulated by nitrogen and carbon sources
- GDH2: expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
- GLN1: expression regulated by nitrogen source and amino acid limitation
- GLT1: expression regulated by nitrogen source
There are 56 pathways listed in the database that L-glutamate participates in
Pathway:
- SGD Pathway
Parameters: The literature contains parameters such as nitrogen feeds, carbon feeds, and conversion rates.

KEG Pathway
This pathway contains a total of 19 enzymes/genes, and there are 12 present in yeast (highlighted).
The information provided in KEGG is similar to SGD but KEGG includes 3-D structures of the enzymes and AA and NT sequences.

@@ Line 13: / Line 13: @@
 **[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13 SGD Pathway]
 **[[image:SGD_Pathway.jpg]]
-*Parameters:
+*Parameters: The literature contains parameters such as nitrogen feeds, carbon feeds, and conversion rates.
 ===KEGG===
@@ Line 19: / Line 19: @@
 *[http://www.kegg.jp/kegg-bin/highlight_pathway?scale=1.0&map=sce00250&keyword=glutamate KEG Pathway]
 *[[image:KEGG_Pathway_edit.jpg]]
-*
+*This pathway contains a total of 19 enzymes/genes, and there are 12 present in yeast (highlighted).
 *The information provided in KEGG is similar to SGD but KEGG includes 3-D structures of the enzymes and AA and NT sequences.