Jacobs:Research:Load-Induced Bone Formation and Skeletal Development: Difference between revisions
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Milos Spasic (talk | contribs) (New page: '''Mechanical stimulation is a potent anabolic stimulus for bone formation''' *Recently we have found that removal of primary cilia ''in vivo'' reduces the ability for mice to form bone in...) |
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*Recently we have found that removal of primary cilia ''in vivo'' reduces the ability for mice to form bone in response to mechanical load. Furthermore, adenylyl cyclase 6 has been identified as a critical mechanosensing protein, and mice lacking AC6 display impaired load-induced bone formation. | *Recently we have found that removal of primary cilia ''in vivo'' reduces the ability for mice to form bone in response to mechanical load. Furthermore, adenylyl cyclase 6 has been identified as a critical mechanosensing protein, and mice lacking AC6 display impaired load-induced bone formation. | ||
*Milos Spasic is utilizing novel therapeutic strategies to promote skeletal mechanosensing in an effort to develop treatments for bone disease. | *Milos Spasic is utilizing novel therapeutic strategies to promote skeletal mechanosensing in an effort to develop treatments for bone disease. | ||
'''Primary cilia are critical for proper skeletal development''' | '''Primary cilia are critical for proper skeletal development''' | ||
*Emily Moore is using unique mouse models to understand the role of the periosteum and primary cilia in skeletal development. | *Emily Moore is using unique mouse models to understand the role of the periosteum and primary cilia in skeletal development. | ||
Latest revision as of 11:49, 20 October 2016
Mechanical stimulation is a potent anabolic stimulus for bone formation
- Recently we have found that removal of primary cilia in vivo reduces the ability for mice to form bone in response to mechanical load. Furthermore, adenylyl cyclase 6 has been identified as a critical mechanosensing protein, and mice lacking AC6 display impaired load-induced bone formation.
- Milos Spasic is utilizing novel therapeutic strategies to promote skeletal mechanosensing in an effort to develop treatments for bone disease.
Primary cilia are critical for proper skeletal development
- Emily Moore is using unique mouse models to understand the role of the periosteum and primary cilia in skeletal development.
