Jacobs
Welcome to the Cell and Molecular Biomechanics Lab! CMBL is part of the Department of Biomedical Engineering at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.
News
- 9/15/2009 The CMBL has an open post-doctoral fellowship in stem cell mechanobiology
- 9/1/2009 The CMBL receives New York State Stem Cell Grant
The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load. The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board ([1]). You can look at the lay abstract of the project here.
Recent updates to the lab wiki
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17 April 2024
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16 April 2024
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N 19:59 | Nanoimprint Lithography (NIL) - Carter Paul 10 changes history +7,205 [CarterPaul (10×)] | |||
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N 18:40 | 3D Cell Culture - McLean Taggart, Emma Villares, Maximillian Marek, Scott LeBlanc, Adam Lyons and Jacob Belden diffhist +24,060 CarterPaul talk contribs (Created page with "{{Template:CHEM-ENG590E}} ==Introduction== While most microfluidic devices incorporate a 2D cell culture design, in which a single layer of cells is grown on the bottom of a device, these systems suffer from poor <i>in vivo</i> mimicry, as, in the human body, most cells grow in all directions.<sup>https://doi.org/10.5114/aoms.2016.63743 1</sup> To address this limitation, 3D cell culture devices have been developed - in w...") |
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10:20 | Yarn Microfluidics - Roger Dirth 12 changes history +442 [Rcostello (12×)] | |||
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08:18 | 3D Printed Microfluidic Robots - Helen Hua 2 changes history +6 [Michele Caggioni (2×)] | |||
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15 April 2024
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22:11 | The paper that launched microfluidics - Xi Ning 12 changes history +5,191 [Xning098 (12×)] | |||
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