IGEM:Stanford/2010/Notebook/11 May 2010

Project Ideas Poll

Hi everyone:

Please choose three ideas from the following list by Wednesday 11:59. When deciding, consider the feasibility, complexity, and your interest in the topic. The top three ideas will then be heavily researched, and will most likely form the basis of the actual project. Also feel free to add any other ideas that are not on the poll.

http://spreadsheets.google.com/ccc?key=0AoaiDJQdUZSYdFkyQWN4WXlUbk95N3BXVGFhejlJTkE&hl=en

Brainstorm/Notes

Preterm Labor:

- one sign of preterm labor is an increase in pH above 4.5, indicating the presence of bacteria (bacterial vaginosis)

• ChvG/ChvI moderates acid-inducible genes in agrobacterium (A global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid)

- labor induced by changes in expression of progesterone receptors, not the steroid itself (Progesterone Withdrawal and Estrogen Activation in Human Parturition Are Coordinated by Progesterone Receptor A Expression in the Myometrium)

- cervical length seems to be an important risk factor

- http://jcem.endojournals.org/cgi/content/abstract/94/6/2066

Concrete:

-Caulobacter crescentus produces a strong glue-like secretion, has been fully sequenced

References brought up during meeting

Temporal Signal Integration

1. Friedland AE, Lu TK, Wang X, Shi D, Church G, and Collins JJ. Synthetic gene networks that count. Science. 2009 May 29;324(5931):1199-202. DOI:10.1126/science.1172005 |

Second generation genetic circuit review:

2. Lu TK, Khalil AS, and Collins JJ. Next-generation synthetic gene networks. Nat Biotechnol. 2009 Dec;27(12):1139-50. DOI:10.1038/nbt.1591 |