IGEM:NYMU/2011: Difference between revisions
(New page: == Goal == Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron. == Why Do We Want to Do That? == Optogenetics, t...) |
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== Goal == | == Goal == | ||
Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron. | Create <b>wireless neuro-stimulator</b>, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron. | ||
== Why Do We Want to Do That? == | == Why Do We Want to Do That? == | ||
Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. | Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. | ||
== Specific Aims == | == Specific Aims == | ||
(1) Wireless stimulation for neurons | <b><font color="blue">(1) Wireless stimulation for neurons</font></b> | ||
(2) Minimization of neuro-immuno response | <b>(2) Minimization of neuro-immuno response</b> | ||
== Our Design == | == Our Design == | ||
To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieveneurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes. | To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieveneurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes. | ||
Revision as of 01:16, 17 December 2012
Goal
Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.
Why Do We Want to Do That?
Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.
Specific Aims
(1) Wireless stimulation for neurons (2) Minimization of neuro-immuno response
Our Design
To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieveneurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes.
Our design is made up of the following two devices:
(1) Optomagnetic Design
Bridging magnetics and optogenetics.
(2) NeuroSymbiosis
Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.
