IGEM:IMPERIAL/2006/project/Oscillator/project browser/Predator Construct: Difference between revisions
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*This part is driving the '''molecular''' events associated with the '''Predator''' in the '''[[IGEM:IMPERIAL/2006/project/Oscillator/Theoretical_Analyses/2D_Model1|Lotka-Volterra model]]'''. | *This part is driving the '''molecular''' events associated with the '''Predator''' in the '''[[IGEM:IMPERIAL/2006/project/Oscillator/Theoretical_Analyses/2D_Model1|Lotka-Volterra model]]'''. | ||
*This part has to interface with the [[IGEM:IMPERIAL/2006/project/Oscillator/project_browser/Prey_Construct|'''Prey-construct''']]. | *This part has to interface with the [[IGEM:IMPERIAL/2006/project/Oscillator/project_browser/Prey_Construct|'''Prey-construct''']]. | ||
*To satify the Lotka-Volterra dynamic of the predator, this part has to | *To satify the Lotka-Volterra dynamic of the predator, this part has to fulfill 3 properties: | ||
**'''Promote the growth of the predator-molecule''' according to the prey and predator populations. | **'''Promote the growth of the predator-molecule''' according to the prey and predator populations. | ||
**'''Kill the prey-molecule''' according to the population of preys and predators | **'''Kill the prey-molecule''' according to the population of preys and predators | ||
**Enable the natural '''death of the predator- | **Enable the natural '''death of the predator-molecule''' | ||
==Part interface== | ==Part interface== | ||
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[[Image:iGEM_IMPERIAL_PreadatorConstructSystemIcon.png|right|350px]] | [[Image:iGEM_IMPERIAL_PreadatorConstructSystemIcon.png|right|350px]] | ||
|} | |} | ||
The '''prey-molecules''' are an '''input''' of the device. They trigger the production of predator-molecules. As a consequence, the '''output''' of this device is a new level of '''prey-molecules''', due to killing, in association with a new level of '''predator-molecules''', due to the balance between growth and natural death. | |||
==Expected behavior and performances== | ==Expected behavior and performances== | ||
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! style="background:lightgrey" width="100pt" |Properties !! colspan="2" | Specifications | ! style="background:lightgrey" width="100pt" |Properties !! colspan="2" | Specifications | ||
|- | |- | ||
| Input Range(s)|| colspan="2" | Input | | Input Range(s)|| colspan="2" | Input range of the prey should at least match the dynamic range of the prey. | ||
|- | |- | ||
| colspan="2" | Output | | rowspan="2"| Output Range(s)|| colspan="2" | Output range of the prey should at least match the dynamic range of the prey. | ||
|- | |- | ||
| | | colspan="2" | Output range of the predator to be defined. | ||
|- | |- | ||
| | | Transfer function(s) || [[Image:IGEM_IMPERIAL_TransferFunctionPredator1.png|250px]] <br> Transfer function inspired by the pure Lotka-Volterra equations, growth predator = C*prey_population_*predator_population|| [[Image:IGEM_IMPERIAL_TransferFunctionPredator2.png|250px]] <br>Transfer function inspired by the pure Lotka-Volterra equations, prey killing = B*prey_population_*predator_population. | ||
|- | |- | ||
| Robustness || colspan="2" | Device should work for at least 10 cycles of the oscillator. | | Robustness || colspan="2" | Device should work for at least 10 cycles of the oscillator to match system level oscillator specifications. | ||
|- | |- | ||
| Variability || colspan="2" | Variability at the population level (day to day, device to device) should be as low as possible | | Variability || colspan="2" | Variability at the device population level (day to day, device to device) should be as low as possible. | ||
|} | |} | ||
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*Getting linear relationship is going to be challenging in a biological system. | *Getting linear relationship is going to be challenging in a biological system. | ||
*Saturation in the response may have to be taken into account (characterized and defined). | *Saturation in the response may have to be taken into account (characterized and defined). | ||
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Latest revision as of 09:43, 30 October 2006
Super Parts | Molecular Prey-Predator Oscillator | |
---|---|---|
Actual Part | ||
Sub Parts | Test Sensing Predator Construct | Test Killing Predator Construct |
Motivations
- This part is driving the molecular events associated with the Predator in the Lotka-Volterra model.
- This part has to interface with the Prey-construct.
- To satify the Lotka-Volterra dynamic of the predator, this part has to fulfill 3 properties:
- Promote the growth of the predator-molecule according to the prey and predator populations.
- Kill the prey-molecule according to the population of preys and predators
- Enable the natural death of the predator-molecule
Part interface
|
The prey-molecules are an input of the device. They trigger the production of predator-molecules. As a consequence, the output of this device is a new level of prey-molecules, due to killing, in association with a new level of predator-molecules, due to the balance between growth and natural death.
Expected behavior and performances
System level specificationsOpen issues
- Getting linear relationship is going to be challenging in a biological system.
- Saturation in the response may have to be taken into account (characterized and defined).
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