IGEM:IMPERIAL/2006/project/Oscillator/project browser/Full System: Difference between revisions
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!height="25pt" width="80pt"|Sub Parts | !height="25pt" width="80pt"|Sub Parts | ||
! [[IGEM:IMPERIAL/2006/project/Oscillator/project browser/Prey_Construct| Prey Generator]] | ! [[IGEM:IMPERIAL/2006/project/Oscillator/project browser/Prey_Construct| Prey Molecule Generator]] | ||
! [[IGEM:IMPERIAL/2006/project/Oscillator/project browser/Predator_Construct| Predator Generator]] | ! [[IGEM:IMPERIAL/2006/project/Oscillator/project browser/Predator_Construct| Predator Molecule Generator]] | ||
|} | |} | ||
<div class="tabs-blue"> | <div class="tabs-blue"> | ||
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{| border="1" width="100%" | {| border="1" width="100%" | ||
|- | |- style="background:blue" | ||
! width="100pt" |Properties !! Comments | |||
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| '''Expected output''' ||align="center" | [[Image:Oscillator output.png|200px| center]] | | style="background:lightblue" width="100pt" |'''Expected output''' ||align="center" | [[Image:Oscillator output.png|200px| center]] | ||
|- | |- | ||
| '''Stability''' ||Oscillations should be stable for greater then 10 cycles. Stable in amplitude, frequency and output profile. | | style="background:lightblue" width="100pt" |'''Stability''' ||Oscillations should be stable for greater then 10 cycles. Stable in amplitude, frequency and output profile. | ||
|- | |- | ||
| '''Variability''' ||Output signal should have a high signal to noise ratio. | | style="background:lightblue" width="100pt" |'''Variability''' ||Output signal should have a high signal to noise ratio. | ||
|- | |- | ||
| '''Flexibility''' ||Amplitude and frequency should be controllable. | | style="background:lightblue" width="100pt" |'''Flexibility''' ||Amplitude and frequency should be controllable. | ||
|- | |- | ||
| '''Amplitude Range'''|| Large enough to have an easy detection. | | style="background:lightblue" width="100pt" |'''Amplitude Range'''|| Large enough to have an easy detection. | ||
|- | |- | ||
| '''Frequency Range'''||From a period of the order of the hour to several hours. | |style="background:lightblue" width="100pt" | '''Frequency Range'''||From a period of the order of the hour to several hours. | ||
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| '''Connectivity''' ||The oscillator should be easily integrated into other more complicated systems. Modular and generic output. | | style="background:lightblue" width="100pt" |'''Connectivity''' ||The oscillator should be easily integrated into other more complicated systems. Modular and generic output. | ||
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| Amplitude tuning | | Amplitude tuning | ||
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|[[Image:Oscillatorblkbox2.png|450px]] | |||
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==Open issues== | ==Open issues== | ||
*In electronic, the stability of the oscillations is a key factor, but the profile of the ouput signal is also an important property of an oscillator. There is an important variety of output profiles used in electronic (harmonic, square-wave, triangle-wave). Sometimes, for a given application a given profile is required. [http://en.wikipedia.org/wiki/Electronic_oscillator read more>>] | *In electronic, the stability of the oscillations is a key factor, but the profile of the ouput signal is also an important property of an oscillator. There is an important variety of output profiles used in electronic (harmonic, square-wave, triangle-wave). Sometimes, for a given application a given profile is required. [http://en.wikipedia.org/wiki/Electronic_oscillator read more>>] | ||
*Due to biological variability, getting a stable behavior might be challenging. | *Due to biological variability, getting a stable behavior might be challenging. | ||
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Latest revision as of 04:36, 31 October 2006
Super Parts | Not Applicable | |
---|---|---|
Actual Part | Full System Logo | |
Sub Parts | Prey Molecule Generator | Predator Molecule Generator |
Motivations
- Oscillators are a fundamental building block in traditional engineering applications (i.e. computers, radio, clocks) , as well as a recurrent motif in many biological systems (i.e.circadian rhythm, menstrual cycle).
- We intend to build a generic and modular synthetic biological oscillator that can become a fundamental building block in future synthetic biological applications.
- Previous oscillators have been attempted (such as the Repressilator by Elowitz and Leibler in 2000) but they often share the following problems:
- Noisy and Unstable (due to stochastic molecular events at the single cell level, cell-cell variability, cell division)
- Damping (i.e.with cell-cell asynchrony)
- Inflexible (i.e. lack of control over amplitude and frequency)
- No easy connectivity (hard to integrate into larger systems)
- Based on these past limitations, we have defined the specifications for our oscillator.
System Specifications
Properties | Comments |
---|---|
Expected output | |
Stability | Oscillations should be stable for greater then 10 cycles. Stable in amplitude, frequency and output profile. |
Variability | Output signal should have a high signal to noise ratio. |
Flexibility | Amplitude and frequency should be controllable. |
Amplitude Range | Large enough to have an easy detection. |
Frequency Range | From a period of the order of the hour to several hours. |
Connectivity | The oscillator should be easily integrated into other more complicated systems. Modular and generic output. |
Part interface
|
Open issues
- In electronic, the stability of the oscillations is a key factor, but the profile of the ouput signal is also an important property of an oscillator. There is an important variety of output profiles used in electronic (harmonic, square-wave, triangle-wave). Sometimes, for a given application a given profile is required. read more>>
- Due to biological variability, getting a stable behavior might be challenging.
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