IGEM:Harvard/2006/Brainstorming Papers - Jeffrey: Difference between revisions
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# quorum1 pmid=15858574 | # quorum1 pmid=15858574 | ||
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'''Basu ''et al.''''' | |||
*Basu ''et al'' created a gene circuit with a non-monotonic response to AHL concentration. | |||
*Main idea: use two concentration boundaries to define three regions with different transcriptional activity | |||
**GFP is repressed at low and high concentrations of AHL, and expressed at medium concentrations | |||
**Basu ''et al.'' created three variants with different upper boundaries | |||
***Concentration varies with distance; thus, a mixture of different variants of bacteria produces a bullseye pattern when exposed to AHL |
Revision as of 11:32, 16 June 2006
Pattern formation and quorum sensing
- Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 2005 Apr 28;434(7037):1130-4. DOI:10.1038/nature03461 |
Basu et al.
- Basu et al created a gene circuit with a non-monotonic response to AHL concentration.
- Main idea: use two concentration boundaries to define three regions with different transcriptional activity
- GFP is repressed at low and high concentrations of AHL, and expressed at medium concentrations
- Basu et al. created three variants with different upper boundaries
- Concentration varies with distance; thus, a mixture of different variants of bacteria produces a bullseye pattern when exposed to AHL