Hoatlin Lab: Difference between revisions

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=Welcome to the Hoatlin Lab Wiki in development.=
{{HoatlinLab}}


Our lab is interested in understanding how the [http://www.fanconi.org/ Fanconi anemia] proteins contribute to genomic stability with the goal of developing drugs that will help Fanconi patients and those who are susceptible to developing cancer.
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We work in [http://www.pova.org/ Portland, Oregon] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology]. Our Departmental web page (not updated frequently) can be viewed [http://www.ohsu.edu/biochem/faculty/faculty.cfm?facultyID=29 here].
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We hope that other Fanconi labs join us at [http://openwetware.org/wiki/Main_Page/ OpenWetWare] because it might stimulate collaborative efforts and facilitate reagent distribution. We also believe that an understanding of the complex and enigmatic Fanconi anemia protein network could benefit from the attention of systems biologists already on OWW.  
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----
'''Lab News'''
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]
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<br>
Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility.  The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility.  Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.  


We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology] and the [http://www.ohsucancer.com/ OHSU Knight Cancer Institute].


==Teaching Links==


*[[Hoatlin:Research Interests|Research Interests]]
*Our lab's Fanconi Anemia antibodies are available from [http://www.novusbio.com Novus Biologicals] and soon by Millipore.
*[[Hoatlin:Lab Members|Lab Members]]
*[[Hoatlin:Publications|Publications]]
*[[Hoatlin:Projects|Projects]]
*[[Hoatlin:Collaborations|Collaborations]]
*[[Hoatlin:Reagent Requests|Reagent Requests]]
*[[Hoatlin: View from our Lab|Our View]]
*[[Hoatlin:Courses and Curriculum Development|Courses and Curriculum Development]]
==[[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club|OHSU Replication, Recombination and Repair (R3) Club]]==


[[Image:Hoatlin_lab_logo.png|frame|"Frog Eggs Rule" illustration by Sobeck&Hoatlin]]
[http://openwetware.org/wiki/CANB_610 Advanced Topics in Cancer Biology (CANB 610)]


[[Simple_wiki_editing_examples|wiki edit instructions]]
[[Hoatlin:OHSU_Genetic_Mechanisms_Class| Genetic Mechanisms Class (CON662)]]
 
[[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club| OHSU DNA Replication, Recombination and Repair (R3) Club]].
 
[[Hoatlin: CSF|Med Students Fundamentals]]
 
==Classes of the past==
[[BMCB625|Advanced Topics in Molecular Biology(BMB625)]]
 
==Who is Visiting Us?==
 
'''Who's visiting?'''
 
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==Basic Wiki/OWW Links==
 
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Revision as of 06:47, 19 August 2014

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

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Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and soon by Millipore.

Advanced Topics in Cancer Biology (CANB 610)

Genetic Mechanisms Class (CON662)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Med Students Fundamentals

Classes of the past

Advanced Topics in Molecular Biology(BMB625)

Who is Visiting Us?

Who's visiting?

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Basic Wiki/OWW Links

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