Hoatlin: Fundamentals: Difference between revisions
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==Links for Maureen Hoatlin's Fundamentals | ==Links for Maureen Hoatlin's Fundamentals 2016 Class== | ||
;Movies for Lecture. We will view several of these movies and discuss together. | |||
*[http://www.hhmi.org/biointeractive/dna-replication-advanced-detail DNA replication animation] | |||
*[http://www. | |||
*[https://www.youtube.com/watch?v=ldXXGt8Ihss DNA polymerase animation] | *[https://www.youtube.com/watch?v=ldXXGt8Ihss DNA polymerase animation] | ||
*[http://www.youtube.com/watch?v=AJNoTmWsE0s telomere animation] | *[http://www.youtube.com/watch?v=AJNoTmWsE0s telomere animation] | ||
*[http://www.youtube.com/watch?v=k4fbPUGKurI topoisomerase] | *[http://www.youtube.com/watch?v=k4fbPUGKurI topoisomerase] | ||
*[https://www.youtube.com/watch?v=bePPQpoVUpM Helicase] | *[https://www.youtube.com/watch?v=bePPQpoVUpM Helicase] | ||
*[http://www. | *extra information if interested in telomeres [http://www.nature.com/scitable/topicpage/Telomeres-of-Human-Chromosomes-21041 Telomeres on Nature Network] | ||
;Materials for the Skills Session on XP | |||
*[http://www. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983582/ DNA repair diseases: What do they tell us about cancer and aging]. Scan before the XP session. | ||
*[http://www.ncbi.nlm.nih.gov/pubmed/22217736 J. DiGiovanna & K. Kraemer, “Shining a Light on Xeroderma Pigmentosum"]. J Invest Dermatol. (2012), 132, 785-96. Scan this review. This is for in-depth understanding, written by Ken Kraemer, an XP expert. | |||
*[http://www. | *When the Lifeguard for the Gene Pool Goes on Strike. A January 2014 seminar by Ken Kraemer on XP. Shows patient cases and outcomes. Some of these slides will be shown during the introduction to the workshop. https://www.youtube.com/watch?v=_z0kEsvCw9k | ||
*NIH Summary of Xeroderma Pigmentosum. http://www.ncbi.nlm.nih.gov/books/NBK1397/ | |||
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==Questions and Answers== | ==Questions and Answers== | ||
*Taken from emailed questions | *Taken from emailed questions over the years about topics I cover including transcription, chromosome and gene structure, DNA replication and DNA repair. Thank you to all students who have contributed these questions--we all benefit: | ||
;Question | ;Question | ||
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;Comment | ;Comment | ||
* there was a typo in lecture notes. the haploid human genome is 3x10^9 (billion) | * there was a typo in lecture notes. the haploid human genome is 3x10^9 (billion) | ||
== Archived Links for previous Classes== | |||
*[http://www.youtube.com/watch?v=aVgwr0QpYNE Splicing animation] | |||
*[http://www.youtube.com/watch?v=SMtWvDbfHLo transcription animation] | |||
*[http://www.youtube.com/watch?v=4jtmOZaIvS0&feature=related DNA Replication] **note: mute the idiotic sound and voiceover and imagine instead the original soundtrack of a machine perking along. | |||
*[https://www.youtube.com/watch?v=ldXXGt8Ihss DNA polymerase animation] | |||
*[http://www.youtube.com/watch?v=AJNoTmWsE0s telomere animation] | |||
*[http://www.nature.com/scitable/topicpage/Telomeres-of-Human-Chromosomes-21041 Telomeres on Nature Network] | |||
*[http://www.youtube.com/watch?v=k4fbPUGKurI topoisomerase] | |||
*[https://www.youtube.com/watch?v=bePPQpoVUpM Helicase] | |||
*[http://www.youtube.com/watch?v=GLwCs370IGI Lectures on genomics] 13 week Series on Genomics 2012 on YouTube | |||
*[http://www.ted.com/talks/lang/eng/paul_rothemund_details_dna_folding.html Crazy Fun with DNA] A TED talk on DNA origami. | |||
Really. | |||
*[http://www.ted.com/talks/david_bolinsky_animates_a_cell.html Animation in Science Education] A TED talk to watch during a break from your studies. | |||
*Enjoy some [http://www.xvivo.net/zirus-antivirotics-condensed/ excellent animations]. The virology animation includes viral replication. Viral styles of replication are complex and fascinating, also providing a target for therapeutic intervention. | |||
*[http://www.youtube.com/watch?v=IMeJA_inoEM&feature=related Pharmacogenomics Video Lecture] | |||
*[http://www.genome.gov/SP2011/ Short Easy reading summary of genomics and medicine] | |||
==Other Stuff== | ==Other Stuff== |
Revision as of 09:27, 3 August 2016
Home Projects Team Papers Contact Us Protocols Collaborations News Reagent Requests secret back door Hoatlin Lab Twitter
Links for Maureen Hoatlin's Fundamentals 2016 Class
Questions and Answers
Reversible modification of the ε-amino group of lysine by acetylation neutralizes a negative charge on DNA.
Transcription factors can be constitutively-active – present in all cells at all times or can be conditionally-active – requires activation (e.g., cell specific or signal-dependent).
That's how PARP1 inhibitors are relatively selective in killing the HR deficient tumor cell but not the wild-type cell (which is competent for HR)
Archived Links for previous Classes
Really.
Other Stuff |