Biochemical analysis of FA protein complexes. We are using biochemical assays in Xenopus cell–free extracts together with assays in human cells to identify functionally important proteins and protein complexes in the FA network.
The role of the FA proteins at early stages of hematopoiesis. We identified
a novel transcriptional repressor (FAZF, for Fanconi Anemia Zinc
Finger) that binds to FANCC, one of the Fanconi proteins. We are interested in the functional consequences of this interaction in
normal and dysregulated hematopoiesis.
We use proteins from frog eggs to understand the basics about how the Fanconi proteins are involved in DNA replication and repair.