Hoatlin:Projects

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{{HoatlinLab}}
{{HoatlinLab}}
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'''Biochemical analysis of FA protein complexes.''' We are using biochemical assays in Xenopus cell–free extracts together with assays in human cells to identify functionally important proteins and protein complexes in the FA network.
'''Biochemical analysis of FA protein complexes.''' We are using biochemical assays in Xenopus cell–free extracts together with assays in human cells to identify functionally important proteins and protein complexes in the FA network.
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'''The role of the FA proteins at early stages of hematopoiesis.'''  We identified
'''The role of the FA proteins at early stages of hematopoiesis.'''  We identified
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Finger) that binds to FANCC, one of the Fanconi proteins. We are interested in the functional consequences of this interaction in
Finger) that binds to FANCC, one of the Fanconi proteins. We are interested in the functional consequences of this interaction in
normal and dysregulated hematopoiesis.
normal and dysregulated hematopoiesis.
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[[Image:frog.png|300px|thumbnail|left|We use proteins from frog eggs to understand the basics about how the Fanconi proteins are involved in DNA replication and repair.]]
[[Image:frog.png|300px|thumbnail|left|We use proteins from frog eggs to understand the basics about how the Fanconi proteins are involved in DNA replication and repair.]]

Revision as of 18:49, 5 October 2006

Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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Biochemical analysis of FA protein complexes. We are using biochemical assays in Xenopus cell–free extracts together with assays in human cells to identify functionally important proteins and protein complexes in the FA network.


The role of the FA proteins at early stages of hematopoiesis. We identified a novel transcriptional repressor (FAZF, for Fanconi Anemia Zinc Finger) that binds to FANCC, one of the Fanconi proteins. We are interested in the functional consequences of this interaction in normal and dysregulated hematopoiesis.


We use proteins from frog eggs to understand the basics about how the Fanconi proteins are involved in DNA replication and repair.
We use proteins from frog eggs to understand the basics about how the Fanconi proteins are involved in DNA replication and repair.
  • Thanks to the Heald lab for this little gal....frogwalk.gif
Fanconi protein FANCC, engineered with a red fluorescent tag, expressed in human cells
Fanconi protein FANCC, engineered with a red fluorescent tag, expressed in human cells




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