Hoatlin:OHSU Knight Cancer Institute Advanced Topics in Cancer Biology

Home        Faculty        Graduate Program        Postdocs        OHSU Knight Core Facilities       

Programs     Res Group Meetings        Cancer Journal Club        Cell/CANB 616        Gen. Inst/R3 Club     CANB 610    

Objectives of the Advanced Topics in Cancer Biology class (CELL 616)

This upper level course will provide clinical insight into cancer research. We have designed this course to address mechanism and current therapeutic options for cancer treatment in the first part of the course. The second part of the course is designed to examine the current state of clinical diagnoses and treatment of different types of cancers that afflict different organ systems. These lectures are designed to address the state of the art and to provide insight into where the field is moving in the future. The overall goal of this course is to provide the current state of the field from a clinical standpoint in anticipation that this knowledge will then be applied to guiding important findings in basic research.

Logistics

• When and where we meet

RJH 5501

The class will run every Spring term

Mon, Wed: 1:30-3:00 PM; Thurs: 1:30-2:30 PM

Mon, Wed class is one hour lecture followed by discussion, Thurs class is presentation of a relevant journal article

• Organizer contact information: searsrATohsu.edu, wongmeATohsu.edu

Participants, Expectations and Grading

• The class is open for registration to all second year and above students. The class is also open to postdoctoral fellows for informal auditing. Please contact the organizers with any questions regarding participation.

• Participants are required to attend at least one tumor board meeting of their choice:

1. Gastrointestinal Tumor Board, 7AM, Thursday, Hatfield 14D03(occasionally is canceled)

2. Breast Tumor Board, 8:30AM, Thursday, Hatfield 14D03

3. Hem/Onc Tumor Board, 8AM, Wednesday, Hatfield 14D03, Lymphoma, leukemia alternate every other week

(occasionally not held if an outside speaker is scheduled)

4. Sarcoma tumor board, 12:30-1:30 PM, Wednesday, Hatfield 14D03(except for the 4th Wednesday of each month)

• Each participant will present a tumor board presentation as follows:

20 minutes in length, powerpoint presentation format, include:

1. Background (cancer type, stage, grade, what is known about this cancer)

2. Known molecular pathways underlying the disease and any potential therapeutic treatments

3. Present the issues discussed related to the individual patient you will be discussing

4. What was the course of actions? And follow-up? Prognosis?

5. Your insights or interests pertaining to this case.

• For students, your grade will be based upon three criteria:

1. Class participation (30%)

(Your journal presentation participation and how interactive you are during the lecture)

2. Your tumor board presentation (30%)

3. Final Exam (40%)

(This exam is a written review of one cancer type (your choice))

Within this review you will include information addressing: background on this type of cancer, demographics, current therapies, known molecular mechanisms, molecular :and animal models that exist, cutting edge research being performed to elucidate the underlying molecular pathway and/or development of novel therapeutics.

Student and Potdoctoral Participants

• Bicocca, Vincent: BicoccavATohsu.edu
• Donley, Nathan: DonleynATohsu.edu
• Laederich, Melanie: LaedericATohsu.edu
• Levin, Trevor: LevintATohsu.edu
• Saadoun, Basma: basmaATpdx.edu ; saadounATohsu.edu
• Van Hook, Katy: VanhookkATohsu.edu
• Xie, Liangqi: xielATohsu.edu

Schedule

Date	Presenters	Topic	Links & attachments
30-Mar	M. Turker	Mutagenic mechanisms
1-Apr	M. Kulesz-Martin	Clinical carcinogenesis
2-Apr	Class participants	Journal (Turker)	O'Hagan (2008) Powerpoint
6-Apr	R. Sears	Metastasis and angiogenesis	Lecture notes
8-Apr	M. Troxel	Solid cancer pathology	Lecture notes part 1 Lecture notes part 2
9-Apr	Class participants	Journal (Troxel)	Wiesener (2001) Powerpoint
13-Apr	C. Lopez	Targeted Cancer Therapeutics	Lecture notes
15-Apr	B. Fox	Immunotherapy	Lecture notes
16-Apr	Class participants	Journal (J. Gallegos)	Cetuximab review EGFR/CRC review Jhawer (2008) Powerpoint
20-Apr	C. Okada	Hematology pathology	Lecture notes
22-Apr	M. Wong	Cancer stem cells
23-Apr	Class participants	Journal (Wong)	Dylla (2008) Supp. data Questions to cover Editable Figures for 4-19-09
27-Apr	W. Fleming	Acute hematologic malignancies	Lecture notes
29-Apr	M. Dieninger	Chronic hematologic malignancies	Lecture notes
30-Apr	Class participants	Journal (Fleming)
4-May	K. Nazemi	Pediatric brain cancer	Lecture notes
6-May	J. Alumkai	Prostate	Lecture notes
7-May	Class participants	Journal (Nazemi - time TBA)	Hallahan (2003) Powerpoint
11-May	A. Blauvelt	Skin cancer
13-May	S. Chui	Breast cancer	Lecture notes
14-May	SRF	class cancelled
18-May	C. Lopez	Gastro Intestinal Cancer	Lecture notes
20-May	G. Vacarro	Pancreatic Cancer	Lecture notes
21-May	Deffebach	Lung Cancer
25-May	Class Cancelled	Memorial Day
27-May	C. Thomas	Radiation Oncology
28-May	E. Neuwelt	Adult Brain Cancer	Lecture notes Neuwelt-Final (2008) Neuwelt-Muldoon (2007) Neuwelt-Angelov (2009)
1-Jun	Class Participants	Tumor board presentations
3-Jun	Class Participants	Tumor board presentations	Katy's presentation
4-Jun	N. Gross	Head & Neck cancer	Lecture notes
8-Jun	J. Shannon	Nutrition and cancer	Lecture notes
10-Jun	C. Ryan	Sarcoma
11-Jun	Class Participants	Journal (Ryan)