Hoatlin:OHSU Genetic Mechanisms Class: Difference between revisions
Line 23: | Line 23: | ||
==Other Bonus Material== | ==Other Bonus Material== | ||
;Question: | ;Question: | ||
When you were talking about DNA replication a "licensing factor" was mentioned, and I was wondering, is this a protein? And what is it's function? | |||
;Answer: | ;Answer: |
Revision as of 11:30, 3 October 2013
Home Projects Team Papers Contact Us Protocols Collaborations News Reagent Requests secret back door Hoatlin Lab Twitter
Links for Maureen Hoatlin's CON 662 Class Oct 2013Bonus Materials
Really.
Other Bonus Material
When you were talking about DNA replication a "licensing factor" was mentioned, and I was wondering, is this a protein? And what is it's function?
Yes licensing factor is the old name for a set of proteins that bind to the origins. Licensing factor is now thought to include the proteins Cdc6 and Cdt1. These proteins bind to the origin recognition complex proteins, and are synthesized only in a specific phase of the cell cycle (G1). Once replication origins "fire" (or start) these proteins are degraded or exported and the origin can't be "licensed" for firing again until the proteins are synthesized and enter the nucleus in the next cell cycle. That's how the cell controls replication so that the DNA is replicated once and only once.
Post TestLinks For Maureen Hoatlin's CON 662 Class Oct 2009 |