Hikmet GECKIL Genetic Engineering Lab: Difference between revisions

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&bull; [[User:Hikmet Geckil|Hikmet Geckil]] (PI)<BR>
&bull; [[User:Hikmet Geckil|Hikmet Geckil]] (PI)<BR>
&bull; [[User:Emel Aytan|Emel Aytan]]<BR>
&bull; [[User:Okan Özşahin|Okan Özşahin]]<BR>
&bull; [[User:Özgür Yilmaz|Özgür Yilmaz]]<BR>
 
&bull; [[User:Veyis Selen|Veyis Selen]]<BR>
ALUMNI<BR>
ALUMNI<BR>
&bull; [[User:Fethiye Sevimli|Fethiye Sevimli]]<BR>
&bull; [[User:Aslı Giray Kurt|Aslı Giray Kurt]]<BR>
&bull; [[User:Aslı Giray Kurt|Aslı Giray Kurt]]<BR>
&bull; [[User:Salih Gencer|Salih Gencer]]<BR>
&bull; [[User:Salih Gencer|Salih Gencer]]<BR>
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&bull; [[User:Venhar Çelik|Venhar Çelik]]<BR>
&bull; [[User:Venhar Çelik|Venhar Çelik]]<BR>
&bull; [[User:Irmak İçen|Irmak İçen]]<BR>
&bull; [[User:Irmak İçen|Irmak İçen]]<BR>
&bull; [[User:Emel Aytan|Emel Aytan]]<BR>
&bull; [[User:Veyis Selen|Veyis Selen]]<BR>
&bull; [[User:Züleyha Türkoğlu|Züleyha Türkoğlu]]<BR>
&bull; [[User:Züleyha Türkoğlu|Züleyha Türkoğlu]]<BR>
UNDERGRADS<BR>
UNDERGRADS<BR>
&bull; [[User:Elif Sakız|Elif Sakız]]<BR>
&bull; [[User:Elif Sakız|Elif Sakız]]<BR>
&bull; [[User:Ferhat Öçal|Ferhat Öçal]]<BR>
&bull; [[User:İrem Ekici|İrem Ekici]]<BR>
&bull; [[User:Işın Korkmaz|Işın Korkmaz]]<BR>
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T: (422)377-3779<BR>
T: (422)377-3779<BR>
F: (422)341-0037<BR>
F: (422)341-0037<BR>
hgeckil@inonu.edu.tr
hgeckil@gmail.com
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<p style="text-align:justify">Research in the <strong>GECKIL GENETIC ENGINEERING LABORATORY</strong> has a long standing interest in the function of Vitreoscilla hemoglobin (VHb), the first prokaryotic hemoglobin. The cloning of the VHB gene (vgb) in diverse organisms and its potential in metabolic engineering using a combination of techniques spanning biochemistry, genetics and molecular biology are the central themes of our study. Our overreaching goal is to shed some light on the function of VHb in its native host and the use of this highly efficient metabolic modulator in production of some industrially important microbial products whose genes are regulated by oxygen. “Asparaginase”, an enzyme used in cancer chemotherapy and “dopa” and “dopamine”, drugs used in Alzheimer's and Parkinson diseases, are the main products under investigation. One of the recent endeavors of our laboratory is to understand the role of mTOR signal complex on the “aerobic glycolysis of cancer cells” also known as Warburg effect, one of the 10 hallmarks of all cancers.
<p style="text-align:justify">Research in Geckil’s Genetic Engineering Laboratory is primarily based on the function of Vitreoscilla hemoglobin (VHb), the first prokaryotic hemoglobin. Using VHb, Geckil’s group engineered various bacteria for the purpose of producing industrially important products ranging from microbial fuels butanediol, acetoin to drugs used in Alzheimer’s and Parkinson disease (e.g., dopa, dopamine) and to asparaginase, an enzyme used in cancer chemotherapy. One of the recent endeavors of his laboratory is to dissect the anatomy of the SARS-CoV-2 Spike (S) protein and its physiological effects on cells. For this aim, his laboratory is studying the expression of S and its effect on cell physiology, using recombinant shuttle vectors created in his laboratory.
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Latest revision as of 15:33, 31 August 2022

The GECKIL Genetic Engineering Laboratory
PI: Hikmet Geckil, Professor of Molecular Genetics
Department of Molecular Biology and Genetics, Inonu University
44280 Malatya, Turkey

Contact Us

Department of Molecular Biology and Genetics
Inonu University
44280 Malatya, Turkey
T: (422)377-3779
F: (422)341-0037
hgeckil@gmail.com

Research in Geckil’s Genetic Engineering Laboratory is primarily based on the function of Vitreoscilla hemoglobin (VHb), the first prokaryotic hemoglobin. Using VHb, Geckil’s group engineered various bacteria for the purpose of producing industrially important products ranging from microbial fuels butanediol, acetoin to drugs used in Alzheimer’s and Parkinson disease (e.g., dopa, dopamine) and to asparaginase, an enzyme used in cancer chemotherapy. One of the recent endeavors of his laboratory is to dissect the anatomy of the SARS-CoV-2 Spike (S) protein and its physiological effects on cells. For this aim, his laboratory is studying the expression of S and its effect on cell physiology, using recombinant shuttle vectors created in his laboratory.

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