Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2012/11/16: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
Caroline Hom (talk | contribs) |
(fix raw html notebook nav) |
||
(6 intermediate revisions by one other user not shown) | |||
Line 2: | Line 2: | ||
|- | |- | ||
|style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> Project name</span> | |style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> Project name</span> | ||
|style="background-color: #F2F2F2" align="center"| | |style="background-color: #F2F2F2" align="center"|[[File:Report.png|frameless|link={{#sub:{{FULLPAGENAME}}|0|-11}}]][[{{#sub:{{FULLPAGENAME}}|0|-11}}|Main project page]]<br />{{#if:{{#lnpreventry:{{FULLPAGENAME}}}}|[[File:Resultset_previous.png|frameless|link={{#lnpreventry:{{FULLPAGENAME}}}}]][[{{#lnpreventry:{{FULLPAGENAME}}}}{{!}}Previous entry]] }}{{#if:{{#lnnextentry:{{FULLPAGENAME}}}}|[[{{#lnnextentry:{{FULLPAGENAME}}}}{{!}}Next entry]][[File:Resultset_next.png|frameless|link={{#lnnextentry:{{FULLPAGENAME}}}}]]}} | ||
|- | |- | ||
| colspan="2"| | | colspan="2"| | ||
<!-- ##### DO NOT edit above this line unless you know what you are doing. ##### --> | <!-- ##### DO NOT edit above this line unless you know what you are doing. ##### --> | ||
==Genes of Focus== | ==Genes of Focus== | ||
There is a threshold of > 10^-3 | |||
<br/> | |||
'''HepG2''' | '''HepG2''' | ||
*TBD | *TBD | ||
'''K562''' | '''K562''' | ||
<br/> | <br/> | ||
''MAP Kinase Activity'' | |||
<br/> | <br/> | ||
1. MAPK14 | 1. MAPK14 | ||
Line 20: | Line 22: | ||
3. MAPK10 | 3. MAPK10 | ||
*Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | *Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | ||
''Phosphotransferase activity, alcohol group as acceptor'' | |||
<br/> | <br/> | ||
4. RET | |||
* | *This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. | ||
*Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. | |||
5. FGFR4 | |||
*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | |||
6. CDKN1A | |||
*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | |||
*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. | |||
*Plays a regulatory role in S phase DNA replication and DNA damage repair. | |||
*May be instrumental in the execution of apoptosis following caspase activation. | |||
'''SK-N-SH RA''' | '''SK-N-SH RA''' | ||
<br/> | |||
''Signaling receptor activity'' | |||
<br/> | |||
1. KIT | |||
*This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. | |||
*Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. | |||
2. TNFRSF11A | |||
*TNF-receptor superfamily (tumor necrosis factor) | |||
3. EGFR | |||
*Mutations in this gene are associated with lung cancer. | |||
''Sequence-Specific DNA Binding'' | |||
<br/> | |||
4. WT1 | |||
*It is mutated in a small subset of patients with Wilm's tumors | |||
5. HLF | |||
*Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. | |||
6. BCL6 | |||
*This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. | |||
<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### --> | <!-- ##### DO NOT edit below this line unless you know what you are doing. ##### --> | ||
|} | |} |
Latest revision as of 22:16, 26 September 2017
Project name | Main project page Previous entry Next entry |
Genes of FocusThere is a threshold of > 10^-3
K562
2. MAPK9
3. MAPK10
Phosphotransferase activity, alcohol group as acceptor
5. FGFR4
6. CDKN1A
SK-N-SH RA
2. TNFRSF11A
3. EGFR
Sequence-Specific DNA Binding
5. HLF
6. BCL6
|