Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.


  • Cameron Gardner's Spring/Fall 2014 project in the Haynes Lab at Arizona State University (continuation of student Brady Laughlin's project).
  • Cameron was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2014 and Fall 2014 semesters.

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