Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.


  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University
  • BME 394 Honors Research Project

Recent changes

21 October 2014

+ N    20:45 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/20‎ (2 changes) . . (+4,225) . . (Page history) [Cameron Lee Gardner‎ (2×)]
       20:38 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/11 (diff; hist) . .  (+139) . . Cameron Lee Gardner (Talk | contribs) (Summary: )

20 October 2014

       13:45 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/11 (diff; hist) . .  (+157) . . Karmella Haynes (Talk | contribs) (Summary: )

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