Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University


Recent changes

16 September 2014

+      16:42 Haynes Lab:Notebook/Engineering PC-TFs/2014/09/15‎ (2 changes) . . (+1,486) . . (Page history) [Cameron Lee Gardner‎ (2×)]

15 September 2014

       20:09 Haynes Lab:Notebook/Engineering PC-TFs/2014/09/15 (diff; hist) . .  (+52) . . Karmella Haynes (Talk | contribs) (Summary: )


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