Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.


  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University

Recent changes

14 September 2014

13 September 2014

+ N    20:35 Haynes Lab:Notebook/Engineering PC-TFs/2014/09/13‎ (4 changes) . . (+1,349) . . (Page history) [Cameron Lee Gardner‎ (4×)]
+ N    20:06 Haynes Lab:Notebook/Engineering PC-TFs/2014/09/12‎ (2 changes) . . (+1,462) . . (Page history) [Cameron Lee Gardner‎ (2×)]

8 September 2014

+ N    16:11 Haynes Lab:Notebook/Engineering PC-TFs/2014/09/08‎ (2 changes) . . (+1,003) . . (Page history) [Cameron Lee Gardner‎ (2×)]

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