Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University
  • BME 394 Honors Research Project


Recent changes

16 October 2014

+      12:46 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/13‎ (2 changes) . . (+26) . . (Page history) [Cameron Lee Gardner‎ (2×)]

14 October 2014

+      02:39 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/13‎ (3 changes) . . (0) . . (Page history) [Cameron Lee Gardner‎ (3×)]

13 October 2014

+ N    18:41 Haynes Lab:Notebook/Engineering PC-TFs/2014/10/13‎ (2 changes) . . (+1,932) . . (Page history) [Cameron Lee Gardner‎ (2×)]


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