Haynes Lab:Notebook/Engineering PC-TFs
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==Project Description/Abstract== | ==Project Description/Abstract== | ||
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* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically. | * Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically. | ||
==Notes== | ==Notes== | ||
| - | * Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University | + | * Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University |
* BME 394 Honors Research Project | * BME 394 Honors Research Project | ||
| + | *Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 semester. | ||
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