Haynes Lab:Notebook/Engineering PC-TFs

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==Project Description/Abstract==
==Project Description/Abstract==
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* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
==Notes==
==Notes==
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* Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University
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* Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University
* BME 394 Honors Research Project
* BME 394 Honors Research Project
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*Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 semester.

Revision as of 18:43, 7 December 2012

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University
  • BME 394 Honors Research Project
  • Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 semester.


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