Haynes Lab:Notebook/Engineering PC-TFs

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==Project Description/Abstract==
==Project Description/Abstract==
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[[Image:engineering_pctfs.jpg|thumb|right|]]
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* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
==Notes==
==Notes==
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* Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University
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* Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University
* BME 394 Honors Research Project
* BME 394 Honors Research Project
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*Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 semester.

Revision as of 18:43, 7 December 2012

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University
  • BME 394 Honors Research Project
  • Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 semester.


Recent changes

10 July 2014

+ N    16:48 Haynes Lab:Notebook/Engineering PC-TFs/2014/07/09‎ (5 changes) . . (+3,127) . . (Page history) [Cameron Lee Gardner‎ (5×)]
+ N    15:38 Haynes Lab:Notebook/Engineering PC-TFs/2014/07/08‎ (3 changes) . . (+2,168) . . (Page history) [Cameron Lee Gardner‎ (3×)]

9 July 2014

+      01:02 Haynes Lab:Notebook/Engineering PC-TFs/2014/07/07‎ (2 changes) . . (+3) . . (Page history) [Cameron Lee Gardner‎ (2×)]


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