Haynes Lab:Notebook/Engineering PC-TFs

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==Project Description/Abstract==
==Project Description/Abstract==
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* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Revision as of 22:40, 15 February 2012

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University
  • BME 394 Honors Research Project


Recent changes

23 November 2014

+ N    00:38 Haynes Lab:Notebook/Engineering PC-TFs/2014/11/12‎ (3 changes) . . (+2,098) . . (Page history) [Cameron Lee Gardner‎ (3×)]
+ N    00:20 Haynes Lab:Notebook/Engineering PC-TFs/2014/11/11‎ (3 changes) . . (+1,469) . . (Page history) [Cameron Lee Gardner‎ (3×)]
       00:14 Haynes Lab:Notebook/Engineering PC-TFs/2014/11/10 (diff; hist) . .  (+8) . . Cameron Lee Gardner (Talk | contribs) (Summary: )

22 November 2014

+ N    23:26 Haynes Lab:Notebook/Engineering PC-TFs/2014/11/10‎ (3 changes) . . (+4,333) . . (Page history) [Cameron Lee Gardner‎ (3×)]


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