Haynes Lab:Notebook/Engineering PC-TFs

(Difference between revisions)

Revision as of 18:15, 19 November 2011

Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University

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 ==Project Description/Abstract==
-* Synthetic biology is an exciting new field that aims to create
+* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
-novel biological functions by artificially combining natural molecular
-parts. Rational design allows us to engineer the behaviors of
-protein-based drugs, in ways that we cannot accomplish with small
-molecule-based drugs. DNA assembly will be used to build a combinatorial
-library of over 200 synthetic transcription factors (Pc-Tfs) that will
-potentially activate therapeutic genes in cancer and stem cells. As time
-allows, a select group of Pc-TF protein will be purified and analyzed
-biochemically.
 ==Notes==