Haynes Lab:Notebook/Engineering PC-TFs

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(Project Description/Abstract)
(Project Description/Abstract)
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==Project Description/Abstract==
==Project Description/Abstract==
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* Synthetic biology is an exciting new field that aims to create
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* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.
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novel biological functions by artificially combining natural molecular
+
-
parts. Rational design allows us to engineer the behaviors of
+
-
protein-based drugs, in ways that we cannot accomplish with small
+
-
molecule-based drugs. DNA assembly will be used to build a combinatorial
+
-
library of over 200 synthetic transcription factors (Pc-Tfs) that will
+
-
potentially activate therapeutic genes in cancer and stem cells. As time
+
-
allows, a select group of Pc-TF protein will be purified and analyzed
+
-
biochemically.
+
==Notes==
==Notes==

Revision as of 18:15, 19 November 2011

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University


Recent changes

19 July 2014

+      16:14 Haynes Lab:Notebook/Engineering PC-TFs/2014/07/09‎ (2 changes) . . (+618) . . (Page history) [Cameron Lee Gardner‎ (2×)]


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