Haynes Lab
From OpenWetWare
Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS
Synthetic chromatin for cell differentiation
- David Barclay (FURI & SynBERC, BS) - pancreas, Jan Simper (FURI, BS) - cardiac
- Description: Testing the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to determine its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's.
Editing synthetic genes using CRISPR
- René Davis (Biological Design, PhD)
- Description: Characterizing chromatin/CRISPR interactions. Re-engineering synthetic gene circuits in human cells using CRISPR.
Engineering synthetic chromatin transcription factors
- Cameron Gardner (FURI, BS)
- Description: Building and testing re-engineered versions of the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011.
Microbial communication with synthetic quorum sensing
- René Davis (Biological Design, PhD), Ryan Muller (SOLUR, BS)
- Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria.
Lab Notebooks - Active
Lab Notebooks - Archived
