- ACS Synthetic Biology - Rene
- Cell - Brendan
- Frontiers in Microbiotechnology – David
- Journal of Biological Engineering - Behzad
- Journal of Cell Biology - Behzad
- Molecular Biology of the Cell - David
- Molecular and Cellular Biology - Rene
- Nature - Brendan
- Nature Biotechnology - Ryan
- Nature Methods - Dr. Haynes
- Nature Molecular Systems Biology - Ryan
- Public Library of Science Biology (PLoS Biology) - Cameron
- Proceedings of the National Academy of Sciences - (orphaned)
- Science - Cameron
- Miscellaneous Reviews and Media - Dr. Haynes
INSTRUCTIONS: Please search for lab-relevant articles dated November 11, 2013 up to today.
Spring 2014, 05/08/2014
Use the following text format EXACTLY as it is shown below...
- (year) Title. Author One, Author Two, and Author Three et al. Journal. Volume:pages. Link.
Summary: Very short explanation of why this paper is relevant/ interesting.
- (2011) Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis. Evan Mills, Xi Chen, Elizabeth Pham, Stanley Wong, and Kevin Truong et al. ACS Synthetic Biology, 1.3:75-82. Link.
Summary: A group from University of Toronto developed a protein that causes rapid apotosis (cell death) of targeted cells.
Open edit mode and copy the example list above. Do not erase the <br><br> tags. Do not use keyboard line returns to space out the numbered list, or else each item will start with the number 1.
ACS Synthetic Biology
Frontiers in Microbiotechnology
Journal of Biological Engineering
Journal of Cell Biology
Molecular Biology of the Cell
Molecular and Cellular Biology
Nature Molecular Systems Biology
Public Library of Science Biology (PLoS Biology)
- (2013) Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes. Emilio Lecona, Luis Alejandro Rojas, Roberto Bonasio et al. Public Library of Science Biology (PLoS Biology). 11(12): e1001737: Link.
Summary: While most work with the Polycomb group of proteins has involved using chromatin modifications to influence the transcriptional status of cell cycle regulators, this study has discovered a transcription-independent function for human Polycomb group proteins in regulating the cell cycle (being the modulation of the progression of cells from G1 into S phase through interacting with p21 to repress CDK2/CYCE complexes during early G1; this does not interact with the Polycomb complex and highlights a relationship between Polycomb's cellular memory and cell-cycle machinery in mammals). The Haynes lab studies the involvement of Polycomb in maintaining chromatin silencing, so although this is not super relevant to our research, it was the most relevant thing I could find in PLoS and is interesting regardless.
Proceedings of the National Academy of Sciences
- (2014) A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis. Bryan J. Wilkins, Nils A. Rall1, Yogesh Ostwal et al. Science. 343:77-80. Link.
Summary: Examined the driving forces of chromatin hypercondensation during mitosis by inserting ultraviolet light inducible cross-linker amino acids in histone proteins of living yeast to trace interactions of proteins along the cell cycle. Found that H3 S10 phosphorylation leads to recruitment of the histone deacetylase Hst2p which removes an acetyl group from histone H4 lysine 16, allowsing the H4 tail to promote fiber condensation on the surface of neighboring nucleosomes. This series of reactions yields a condensin-independent driving force of chromatin hypercondenation during mitosis (where previously it was thought that metaphase chromosome condensation required the condensin complex to remain undisrupted). Although the chromatin marker being researched in this article is H3S10 rather than our marker of interest in the Haynes lab (H3K27me3) I thought the use of ultra violet light could be relevant to Branden's project (although I'm unsure of the details of his work so this may not be the case).
- (2014) Total Synthesis of a Functional Designer Eukaryotic Chromosome. Narayana Annaluru, Héloïse Muller, Leslie A. Mitchell et al. Science. 344:55-58. Link.
Summary: Designer eukaryotic chromosome synthesized based on native Saccharomyces cerevisiae chromosome III. This chromosome is functional in S.cerevisiae. All nonessential genes were made to be flanked by loxPsym sites which enabled inducible evolution and genome reduction; this allows for direct evolutionary testing (e.g. max number of nonessential genes that can be modified or deleted without a catastrophic loss of fitness). This chromosome synthesis is a major and exciting step forward in synthetic biology. Authors postulate that it will soon be feasible to engineer new eukaryotic genomes with synthetic chromosomes encoding desired function and phenotypic properties. Another very exciting component of this breakthrough is that it was accomplished by undergraduate students, demonstrating the significant power of open sourced work and brain pooling.
- (2013) Genetics Driving Epigenetics. Terrence S. Furey, Praveen Sethupathy. Science. 342:705-706. Link.
Summary: I don't think this article needs to be discussed in the meeting, however I thought it was a good (and very short) background on how DNA sequence variation influences epigentics through transcription factor modulated histone tail modificatons and epigenetic mechanisms in general. I would recommend lab members not already familiar with this topic to read it!
Miscellaneous Reviews and Media