Haynes:LitReviewMay2014

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JOURNAL ASSIGNMENTS:

• ACS Synthetic Biology - Rene
• Cell - Brendan
• Frontiers in Microbiotechnology – David
• Journal of Biological Engineering - Behzad
• Journal of Cell Biology - Behzad
• Molecular Biology of the Cell - David
• Molecular and Cellular Biology - Rene
• Nature - Brendan
• Nature Biotechnology - Ryan
• Nature Methods - Dr. Haynes
• Nature Molecular Systems Biology - Ryan
• Public Library of Science Biology (PLoS Biology) - Cameron
• Proceedings of the National Academy of Sciences - (orphaned)
• Science - Cameron
• Miscellaneous Reviews and Media - Dr. Haynes

INSTRUCTIONS: Please search for lab-relevant articles dated November 11, 2013 up to today.

Fall 2013, 11/11/13

Use the following text format EXACTLY as it is shown below...

1. (year) Title. Author One, Author Two, and Author Three et al. Journal. Volume:pages. Link.
   Summary: Very short explanation of why this paper is relevant/ interesting.
   
   
2. (2011) Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis. Evan Mills, Xi Chen, Elizabeth Pham, Stanley Wong, and Kevin Truong et al. ACS Synthetic Biology, 1.3:75-82. Link.
   Summary: A group from University of Toronto developed a protein that causes rapid apotosis (cell death) of targeted cells.
   
   

Open edit mode and copy the example list above. Do not erase the <br><br> tags. Do not use keyboard line returns to space out the numbered list, or else each item will start with the number 1.

ACS Synthetic Biology

1. Item

Cell

1. Item

Frontiers in Microbiotechnology

1. Item

Journal of Biological Engineering

1. Item

Journal of Cell Biology

1. Item

Molecular Biology of the Cell

1. Item

Molecular and Cellular Biology

1. Item

Nature

1. Item

Nature Biotechnology

1. Item

Nature Methods

1. Item

Nature Molecular Systems Biology

1. Item

Public Library of Science Biology (PLoS Biology)

1. Item

Proceedings of the National Academy of Sciences

1. (2013) Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells. Patrick Murphy et. al. Proceedings of the National Academy of Sciences. 110: 19: 7772-7777. Link

Science

1. (2013) Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma. Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, et. al.. Science 340:857-61. Link
   Summary: Found that Lys27Met mutations in histone tails inhibit PRC2 activity in a specific child cancer. Somewhat novel application of therapies being explored in our lab.
   
   

Miscellaneous Reviews and Media

2013 iGEM World Championship - Projects of Interest

1. (2013) COLISWEEPER: The world's first bacterial minesweeper game. ETH Zurich iGEM Team. iGEM World Championship. Link.
   Summary: Biological version of the Minesweeper game. Bacterial spot-cultures (spaced on a grid on agar) represented either mines or number clues (via expression of some combination of colorimetric enzymes). Quorum sensing (Lux) was used to enable the number clue spots to create a certain color depending upon their positioning near one, two, or more mines. Their data included a nice demonstration of AHL-concentration-dependent gene induction.
   
   
2. (2013) E. teamwork: Engineering a synthetic microbial consortium. Braunschweig iGEM Team. iGEM World Championship. Link.
   Summary: Quroum sensing (Las and Rhl) was used to cross-induce ampicillin resistance in cells so that the survival of each relied on eachother. Cell types were "tagged" with pigment expression (blue and pink) in order to quantify the proportion of each in co-culture. The team reported a third strain (labeled yellow) but I only saw data for a two-strain blue/ pink co-culture on their poster.
   
   
3. (2013) Exosome mediated mammalian cell-cell communication. MIT iGEM Team. iGEM World Championship. Link.
   Summary: The Acyl-TyA peptide tag was used to incorporate proteins into mammalian exosomes, which are vesicles that carry "cargo" from one mammalian cell to another. There is data that suggests that cell membrane localization worked, but no data for actual protein delivery (just tests to see if the tag disrupted protein function).
   
   
4. (2013) The uniCAS toolkit for gene regulation. Freiburg iGEM Team. iGEM World Championship. Link.
   Summary: The team used the Cas9 protein/ guide-RNA system to target various transcriptional regulators to genes in mammalian cells. One very cool, straight-forward application was a split transcription activator: Cas9+CRY2 binds DNA, and CIB1+VP16 is required to activate transcription. Blue light stimulates CRY2-CIB1 interaction; as a result, VP16 recruitment to a gene is controlled by light. Note: the Cas9+Vp16 has been published recently.
   
   

News

1. November 6, 2013. BBSRC Invests $16M in Synthetic Biology Startup Fund. GenomeWeb Staff Reporter. GenomeWeb Daily News. Link.
   Summary: Biotechnology and Biological Science Research Council (BBRC) said today that it has provided £10 million ($16.1 million USD) to launch an investment fund that will fund early-stage companies in the United Kingdom that are focused on commercializing synthetic biology technologies
   
   
2. October 24, 2013. SRC launches synthetic biology research effort at six universities. Semiconductor Research Corp. R&D Magazine. Link.
   Summary: Semiconductor Research Corporation (SRC) launched the Semiconductor Synthetic Biology (SSB) research program on hybrid bio-semiconductor systems. The program will initially fund research at six universities: Massachusetts Institute of Technology, the Univ. of Massachusetts at Amherst, Yale, Georgia Tech, Brigham Young, and the Univ. of Washington.