Haynes:LitReviewApr2013

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Spring 2013, 04/09/13

Use the following text format...

1. (year) Title. Author One, Author Two, and Author Three et al. Journal. Volume:pages. Link. Summary: Very short explanation of why this paper is relevant/ interesting.
   
   
2. (2011) Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis. Evan Mills, Xi Chen, Elizabeth Pham, Stanley Wong, and Kevin Truong et al. ACS Synthetic Biology 2012 1.3:75-82. Link. Summary: Group from University of Toronto developed protein that causes rapid cell apotosis (cell death) of targeted cells.
   
   

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ACS Synthetic Biology

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Cell

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Frontiers in Microbiotechnology

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Journal of Biological Engineering

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Journal of Cell Biology

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Molecular Biology of the Cell

1. 2012 Myosin Vs organize actin cables in fission yeast, Libera Lo Presti, Fred Chang, and Sophie G. Martin et al. Molecular Biology of the Cell. Link 23: 4579-91. Summary: Actin filaments serve as tracks for myosin motors. Evidence suggests that myosin contribute to the organization of these actin filaments. Using a synthetic biology approach, they separated the two distinct elements of cargo transport. First, They created a kinesin-myosin chimera, which delivers myosin cargoes across microtubule networks. Second, they linked the nucleus to the myosin motor traveling along actin cables partly restores cable organization. It was determined that the tethering the motor domain of Myo52 to the nucleus increases retrograde flow and cable extension. The in vivo data reveals that there is evidence of a self-organizing system in which myosin motor proteins shape their own tracks.

1. 2011 Coiled-coil networking shapes cell molecular machinery Yongqiang Wanga, Xinlei Zhanga, Hong Zhang et al. Molecular Biology of the Cell. 23: 3911-22 Link Summary: An understanding of the coiled-coil interactions would help reveal the potential for exploration of its function and use in therapeutics. In Saccharomyces cerevisiae (yeast), it is revealed that CCI is functionally involved in cell machinery organization. CCI also plays an important role in the formation of kinetochore, which means that disruption of CCI leads to a defect in the kinetochore assembly. The study characterizes the CCI as a valuable component for shaping and regulation.

Molecular and Cellular Biology

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Nature

1. (2012) DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition Simon J. Elsässer, Hongda Huang, Peter W. Lewis, et al. Nature 491, 560–565 Link Summary: The authors examined DAXX a histone chaperone involved in processing of the histone variant H3.3 prior to assembly into chromatin. For the first time the complete 3D structure of DAXX is reported including 3D structures of DAXX binding to its substrate. Further structure analysis are reported on DAXX mutations and functional binding analyses are performed in vitro and in vivo. For all these assays 3D structures are reported.

Nature Biotechnology

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Nature Methods

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Nature Molecular Systems Biology

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Public Library of Science Biology (PLoS Biology)

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Proceedings of the National Academy of Sciences (PNAS)

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Science

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Miscellaneous Reviews and Media

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