Hartings AU Phosphorylation Lab - Revision history

Matt Hartings at 17:35, 27 January 2012

2012-01-27T17:35:28Z

←Older revision		Revision as of 17:35, 27 January 2012
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	We are synthesizing novel ruthenium-modified adenosine triphosphate (ATP) analogues. These molecules are being designed so that they can be used by kinases to phosphorylate protein-substrates with a ruthenium-modified phosphate group. Additionally, the ruthenated-phosphate group must be inaccessible to phosphatases such that once the protein-substrate is irreversibly phosphorylated. We plan to use these molecules to study and disrupt intracellular communication with a specific focus on cancerous cells. (The image above shows that one of the ruthenium-modified ATP molecules will look like (left) as well as a rendering of a protein structure with a tyrosine that has been phosphorylated with our modified ATP (right)). You can find more information on this lab at our group [http://hartingslab.com/research/phosphorylation website].<br>		We are synthesizing novel ruthenium-modified adenosine triphosphate (ATP) analogues. These molecules are being designed so that they can be used by kinases to phosphorylate protein-substrates with a ruthenium-modified phosphate group. Additionally, the ruthenated-phosphate group must be inaccessible to phosphatases such that once the protein-substrate is irreversibly phosphorylated. We plan to use these molecules to study and disrupt intracellular communication with a specific focus on cancerous cells. (The image above shows that one of the ruthenium-modified ATP molecules will look like (left) as well as a rendering of a protein structure with a tyrosine that has been phosphorylated with our modified ATP (right)). You can find more information on this lab at our group [http://hartingslab.com/research/phosphorylation website].<br>
-	<div style="text-align: center;">[[Image:~~AU BDLabs 1~~.png\|450px]]</div><br>	+	<div style="text-align: center;">[[Image:Hartings_Kinase_phosphatase_s.png\|450px]]</div><br>
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Matt Hartings at 17:33, 27 January 2012

2012-01-27T17:33:59Z

←Older revision		Revision as of 17:33, 27 January 2012
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	{{Template:Hartings AU Phosphorylation Lab}}		{{Template:Hartings AU Phosphorylation Lab}}
	<div style="margin-left: 40px; width: 750px">		<div style="margin-left: 40px; width: 750px">
-	~~The American University Biomaterials Design Lab is~~ a ~~student run and operated laboratory course in~~ the ~~department of chemistry. Our goal is~~ to ~~develop methodology for~~ the ~~chemical modification of biocompatible materials and~~ to ~~tailor~~ these ~~new materials for medical~~ and ~~biotechnological applications~~. ~~Our first semester~~ of ~~research will be~~ the ~~Fall of 2011. The efforts of this first semester~~ will ~~expand off~~ of ~~the work done developing~~ protein ~~films by Bakshi, ''et al''~~ ([~~[doi~~:10.~~1021~~/~~jp110296y~~]]). In this work, the authors synthesize a gold nanoparticle that is templated and solubilized by the protein bovine serum albumin (BSA). They then create a biocompatible film that encapsulates these gold nanoparticles. We will be developing techniques for chemically modifying the protein that encapsulates the gold nanoparticle and will test these methodologies on the nanoparticles while in solution and while in a film.<br>	+	We are synthesizing novel ruthenium-modified adenosine triphosphate (ATP) analogues. These molecules are being designed so that they can be used by kinases to phosphorylate protein-substrates with a ruthenium-modified phosphate group. Additionally, the ruthenated-phosphate group must be inaccessible to phosphatases such that once the protein-substrate is irreversibly phosphorylated. We plan to use these molecules to study and disrupt intracellular communication with a specific focus on cancerous cells. (The image above shows that one of the ruthenium-modified ATP molecules will look like (left) as well as a rendering of a protein structure with a tyrosine that has been phosphorylated with our modified ATP (right)). You can find more information on this lab at our group [http://hartingslab.com/research/phosphorylation website].<br>
	<div style="text-align: center;">[[Image:AU BDLabs 1.png\|450px]]</div><br>		<div style="text-align: center;">[[Image:AU BDLabs 1.png\|450px]]</div><br>
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Matt Hartings at 16:20, 27 January 2012

2012-01-27T16:20:20Z

←Older revision		Revision as of 16:20, 27 January 2012
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-	{{Template:AU ~~Biomaterials Design~~ Lab}}	+	{{Template:Hartings AU Phosphorylation Lab}}
	<div style="margin-left: 40px; width: 750px">		<div style="margin-left: 40px; width: 750px">
	The American University Biomaterials Design Lab is a student run and operated laboratory course in the department of chemistry. Our goal is to develop methodology for the chemical modification of biocompatible materials and to tailor these new materials for medical and biotechnological applications. Our first semester of research will be the Fall of 2011. The efforts of this first semester will expand off of the work done developing protein films by Bakshi, ''et al'' ([[doi:10.1021/jp110296y]]). In this work, the authors synthesize a gold nanoparticle that is templated and solubilized by the protein bovine serum albumin (BSA). They then create a biocompatible film that encapsulates these gold nanoparticles. We will be developing techniques for chemically modifying the protein that encapsulates the gold nanoparticle and will test these methodologies on the nanoparticles while in solution and while in a film.<br>		The American University Biomaterials Design Lab is a student run and operated laboratory course in the department of chemistry. Our goal is to develop methodology for the chemical modification of biocompatible materials and to tailor these new materials for medical and biotechnological applications. Our first semester of research will be the Fall of 2011. The efforts of this first semester will expand off of the work done developing protein films by Bakshi, ''et al'' ([[doi:10.1021/jp110296y]]). In this work, the authors synthesize a gold nanoparticle that is templated and solubilized by the protein bovine serum albumin (BSA). They then create a biocompatible film that encapsulates these gold nanoparticles. We will be developing techniques for chemically modifying the protein that encapsulates the gold nanoparticle and will test these methodologies on the nanoparticles while in solution and while in a film.<br>
	<div style="text-align: center;">[[Image:AU BDLabs 1.png\|450px]]</div><br>		<div style="text-align: center;">[[Image:AU BDLabs 1.png\|450px]]</div><br>
	</div>		</div>

Matt Hartings: New page: {{Template:AU Biomaterials Design Lab}}
The American University Biomaterials Design Lab is a student run and operated laboratory course in the...

2012-01-27T16:15:53Z

New page: {{Template:AU Biomaterials Design Lab}} <div style="margin-left: 40px; width: 750px"> The American University Biomaterials Design Lab is a student run and operated laboratory course in the...

New page

{{Template:AU Biomaterials Design Lab}}
<div style="margin-left: 40px; width: 750px">
The American University Biomaterials Design Lab is a student run and operated laboratory course in the department of chemistry. Our goal is to develop methodology for the chemical modification of biocompatible materials and to tailor these new materials for medical and biotechnological applications. Our first semester of research will be the Fall of 2011. The efforts of this first semester will expand off of the work done developing protein films by Bakshi, ''et al'' ([[doi:10.1021/jp110296y]]). In this work, the authors synthesize a gold nanoparticle that is templated and solubilized by the protein bovine serum albumin (BSA). They then create a biocompatible film that encapsulates these gold nanoparticles. We will be developing techniques for chemically modifying the protein that encapsulates the gold nanoparticle and will test these methodologies on the nanoparticles while in solution and while in a film.<br>
<div style="text-align: center;">[[Image:AU BDLabs 1.png|450px]]</div><br>
</div>

Hartings AU Phosphorylation Lab - Revision history

Matt Hartings at 17:35, 27 January 2012

Matt Hartings at 17:33, 27 January 2012

Matt Hartings at 16:20, 27 January 2012

Matt Hartings: New page: {{Template:AU Biomaterials Design Lab}} The American University Biomaterials Design Lab is a student run and operated laboratory course in the...

Matt Hartings: New page: {{Template:AU Biomaterials Design Lab}}
The American University Biomaterials Design Lab is a student run and operated laboratory course in the...