Harmer Lab: Difference between revisions
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<h2><font style="color:#008000;">Announcements</font></h2> | |||
[[Image:sunflower_cover_small.png|thumb|frame|left|[http://science.sciencemag.org/cgi/content/full/353/6299/587?ijkey=aVhP94O00PDOE&keytype=ref&siteid=sci Our investigation of sunflower solar tracking was recently published in ''Science'']!]] | |||
* A nice description of our recent article investigating the role of the clock in sunflower solar tracking and flower orientation can be found in this [https://www.newscientist.com/article/2100051-mystery-of-why-some-sunflowers-track-the-sun-across-skies-solved/ ''New Scientist'' article]. | |||
*Other popular press coverage includes pieces in [https://www.nytimes.com/2016/08/05/science/how-sunflowers-follow-the-sun-day-after-day.html?rref=collection%2Fcolumn%2Ftrilobites&action=click&contentCollection=science®ion=stream&module=stream_unit&version=latest&contentPlacement=1&pgtype=collection&_r=0 the ''New York Times''], the [http://www.latimes.com/science/sciencenow/la-sci-sn-sunflowers-direction-20160804-snap-story.html ''Los Angeles Times''], and the [https://www.washingtonpost.com/news/speaking-of-science/wp/2016/08/05/watch-a-sunflower-dance-in-the-sun-now-scientists-know-how-its-done/ ''Washington Post'']. | |||
*Links to additional popular press articles, podcasts, and social media references to this work may be found [[Sunflower_press_summary | on this page]]. | |||
*Schedules for [http://malooflab.phytonetworks.org/schedules/group-meeting-summer-2016/ our joint group meeting with the Maloof lab], [https://smartsite.ucdavis.edu/portal/site/5f0e3c4d-70cd-4de6-a3a1-32b178f19d88 our joint journal club with the Chiu lab] and [http://biosci.ucdavis.edu/seminars-and-events/ UC Davis seminars]. | |||
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<h2><font style="color:#4B0082;">Research</font></h2> | |||
Many organisms, including some prokaryotes and most eukaryotes, possess an internal timer or circadian clock that allows them to regulate their physiology to better adapt to our continually changing world. These circadian clocks generate roughly 24 hour rhythms in physiology and behavior that are maintained even in the absence of environmental cues. Although the molecular components of circadian clocks are not conserved across higher taxa, in all organisms studied these clocks are cell autonomous oscillators and in diverse eukaryotes are composed of complex transcriptional networks. | |||
As rooted organisms living in a continually changing world, plants are masters at withstanding environmental variation. The circadian clock is key: it both ensures the optimal timing of daily and seasonal events to cope with predictable stresses and regulates myriad signaling pathways to optimize responses to environmental cues. The study of circadian rhythms in plants thus presents a wide range of fascinating questions with real-world applications: What is the molecular nature of the circadian clock; that is, how can a cell keep time? What aspects of physiology are under circadian regulation? What are the mechanistic links between the clock network and other signaling pathways? Why does a functional circadian clock provide an adaptive advantage? | |||
The Harmer lab is using ''Arabidopsis thaliana'' and sunflower to address these important questions. We use forward and reverse genetics, genomics, biochemistry, and physiological studies to better understand the nature of the plant clock and how it helps shape plant responses to the environment. | |||
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[[Harmer_Lab:Research | Read more...]] | |||
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< | <h2><font style="color:#E30B5C;">Lab Members</font></h2> | ||
*[[Harmer_Lab: | *[[Harmer_Lab:Stacey_Harmer|Stacey Harmer]] | ||
*Hagop Atamian | |||
*Nicky Creux | |||
*[[User:Valentina Fanelli|Valentina Fanelli]] | |||
*[[User:Jennifer_Gray|Jennifer Gray]] | |||
*Rod Kumimoto | |||
*[[User:Akiva Shalit-Kaneh|Akiva Shalit-Kaneh]] | |||
<h3><font style="color:#E30B5C;"> | <h3><font style="color:#E30B5C;">Undergrad & high school interns</font></h3> | ||
* | *Dalena (Nhu) Chu | ||
* | *Emma Goguen | ||
* | *Navdeep Kaur | ||
* | *Rohan Konnur | ||
* | *Kellie Sluga | ||
*Winnifred Toy | |||
*Timothy Youngblood | |||
*Michael Zook | |||
<h2><font style="color:#CA1F7B;">Former Members</font></h2> | |||
*[http://www.mpipz.mpg.de/tsuda/members Shajahan_Anver] | |||
*[http://mfcovington.github.io/ Mike Covington] | |||
*[http://www.mofo.com/people/e/ellison-cory Cory Ellison] | |||
*[http://sites.duke.edu/benfey/people/ Polly (Yingshan) Hsu] | |||
*[http://www.joneslab.co.uk/ Matt Jones] | |||
* Ellen Martin-Tryon | |||
*[http://www.linkedin.com/pub/dir/Reetika/Rawat Reetika Rawat] | |||
*Ivan Salles Santos | |||
*Koby Schwartz | |||
*[http://www.cragenomica.es/staff/detail/nozomu-takahashi Nozomu Takahashi] | |||
*Mikayala Waugh | |||
* Brian Williams | |||
*[[Undergrad Alumni]] | *[[Undergrad Alumni]] | ||
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<h2><font style="color:#DB7093">Funding</font></h2> | |||
*[http://www.nigms.nih.gov/Research/ National Institute of General Medical Sciences] | |||
**[[Harmer_Lab:NIH | Molecular analysis of ''Arabidopsis'' circadian regulation]] | |||
*[http://www.nsf.gov/index.jsp National Science Foundation] | |||
** [[Harmer_Lab:NSF | Investigating the Mechanistic Basis and Adaptive Significance of the Coordination of Plant Growth by External and Internal Cues]] | |||
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<h2><font style="color:#1E90FF;">Recent Publications</font></h2> | |||
*Atamian, H.S., Creux, N.M., Brown, E.A., Garner, A.G., Blackman, B.K., and Harmer, S.L. (2016) Circadian regulation of sunflower heliotropism, floral orientation, and pollinator visits. ''Science''. 353(6299):587-90. doi: 10.1126/science.aaf9793 [http://science.sciencemag.org/cgi/content/full/353/6299/587?ijkey=aVhP94O00PDOE&keytype=ref&siteid=sci] | |||
*Atamian, H.S. and Harmer, S.L. (2016) Circadian regulation of hormone signaling and plant physiology. ''Plant Mol Biol.'' 91(6):691-702. doi: 10.1007/s11103-016-0477-4 [http://link.springer.com/article/10.1007/s11103-016-0477-4] | |||
*Jones, M.A., Hu, W., Litthauer, S., Lagarias, J.C. and Harmer, S.L. (2015) A constitutively active allele of phytochrome B maintains circadian robustness in the absence of light. ''Plant Physiology.'' 169(1):814-25. doi: 10.1104/pp.15.00782 [http://www.plantphysiol.org/content/169/1/814.long] | |||
*Anver, S., Roguev, A., Zofall, M., Krogan, N.J., Grewal, S.I.S., and Harmer, S.L. (2014) Yeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts. ''EMBO reports.'' pii: e201438902. [http://onlinelibrary.wiley.com/doi/10.15252/embr.201438902/abstract] | |||
*Hsu, P.Y. and Harmer, S.L. (2013) Wheels within wheels: the plant circadian system. ''Trends in Plant Science'' [http://dx.doi.org/10.1016/j.tplants.2013.11.007] | |||
*Hsu, P.Y., Devisetty, U.K., and Harmer, S.L. (2013) Cycling activators control the evening arm of the plant clock. ''eLife.'' 2:e00473. [http://elifesciences.org/content/2/e00473] | |||
*Zemach, A., Kim, M.Y., Hsieh, P.-H., Coleman-Derr,D., Eshed-Williams, L., Thao, K, Harmer, S.L., and Zilberman, D. (2013) The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin. ''Cell'' 153(1):193-205 [http://www.cell.com/abstract/S0092-8674%2813%2900222-5] | |||
*Hu, W., Franklin, K.A., Sharrock, R.A., Jones, M.A., Harmer, S.L., and Lagarias, J.C. (2013) Unanticipated regulatory roles for Arabidopsis phytochromes revealed by null mutant analysis. ''Proceedings of the National Academy of the Science'' 110(4) 1542-1547. [http://www.pnas.org/content/110/4/1542.abstract] | |||
*Hsu, P.Y. and Harmer, S.L. (2012) Circadian phase has profound effects on differential expression analysis. ''PLoS One'' 7(11):e49853 [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049853] | |||
*Jones, M.A., Williams, B.A., McNicol J., Simpson, C.G., Brown, J.W., and Harmer, S.L. (2012) Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS 1 causes circadian clock defects. ''Plant Cell'', 24(10):4066-82 [http://www.plantcell.org/content/24/10/4066.long] | |||
*[[Harmer_Lab:Publications | see complete list...]] | |||
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<h2><font style="color:#008000;">Collaborators</font></h2> | |||
[http://people.virginia.edu/~bkb2f/Blackman_Lab/Welcome.html Blackman Lab] | |||
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[http://www.joneslab.co.uk/ Jones Lab] | |||
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[http://www.mcb.ucdavis.edu/faculty-labs/lagarias/ Lagarias Lab] | |||
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[[Maloof_Lab | Maloof Lab]] | |||
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[http://www.researchgate.net/profile/Cinzia_Montemurro Montemurro Lab] | |||
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[http://www.leloir.org.ar/yanovsky/ Yanovsky Lab] | |||
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Revision as of 18:08, 26 August 2016
Room 2123 |
Announcements
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