Harmer Lab: Difference between revisions
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< | <h2><font style="color:#008000;">Announcements</font></h2> | ||
* Our work was recently featured in this [http://www.nature.com/news/video-sunflowers-move-to-internal-rhythm-1.15548 ''Nature'' news article]! | * Our work was recently featured in this [http://www.nature.com/news/video-sunflowers-move-to-internal-rhythm-1.15548 ''Nature'' news article]! | ||
*And here is a [http://biologicalexceptions.blogspot.com/2014/07/east-to-west-and-back-again.html blog post] discussing our research. | *And here is a [http://biologicalexceptions.blogspot.com/2014/07/east-to-west-and-back-again.html blog post] discussing our research. | ||
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< | <h2><font style="color:#4B0082;">Research</font></h2> | ||
Many organisms, including some prokaryotes and most eukaryotes, possess an internal timer or circadian clock that allows them to regulate their physiology to better adapt to our continually changing world. These circadian clocks generate roughly 24 hour rhythms in physiology and behavior that are maintained even in the absence of environmental cues. Although the molecular components of circadian clocks are not conserved across higher taxa, in all organisms studied these clocks are cell autonomous oscillators and in diverse eukaryotes are composed of complex transcriptional networks. | Many organisms, including some prokaryotes and most eukaryotes, possess an internal timer or circadian clock that allows them to regulate their physiology to better adapt to our continually changing world. These circadian clocks generate roughly 24 hour rhythms in physiology and behavior that are maintained even in the absence of environmental cues. Although the molecular components of circadian clocks are not conserved across higher taxa, in all organisms studied these clocks are cell autonomous oscillators and in diverse eukaryotes are composed of complex transcriptional networks. | ||
As rooted organisms living in a continually changing world, plants are masters at withstanding environmental variation. The circadian clock is key: it both ensures the optimal timing of daily and seasonal events to cope with predictable stresses and regulates myriad signaling pathways to optimize responses to environmental cues. The study of circadian rhythms in plants thus presents a wide range of fascinating questions with real-world applications: What is the molecular nature of the circadian clock; that is, how can a cell keep time? What aspects of physiology are under circadian regulation? What are the mechanistic links between the clock network and other signaling pathways? Why does a functional circadian clock provide an adaptive advantage? | As rooted organisms living in a continually changing world, plants are masters at withstanding environmental variation. The circadian clock is key: it both ensures the optimal timing of daily and seasonal events to cope with predictable stresses and regulates myriad signaling pathways to optimize responses to environmental cues. The study of circadian rhythms in plants thus presents a wide range of fascinating questions with real-world applications: What is the molecular nature of the circadian clock; that is, how can a cell keep time? What aspects of physiology are under circadian regulation? What are the mechanistic links between the clock network and other signaling pathways? Why does a functional circadian clock provide an adaptive advantage? | ||
The Harmer lab is using ''Arabidopsis thaliana'' and sunflower to address these important questions. We use forward and reverse genetics, genomics, biochemistry, and physiological studies to better understand the nature of the plant clock and how it helps shape plant responses to the environment. | The Harmer lab is using ''Arabidopsis thaliana'' and sunflower to address these important questions. We use forward and reverse genetics, genomics, biochemistry, and physiological studies to better understand the nature of the plant clock and how it helps shape plant responses to the environment. | ||
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[[Harmer_Lab:Research | | <br/> | ||
[[Harmer_Lab:Research | Read more...]] | |||
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< | |||
<h2><font style="color:#E30B5C;">Lab Members</font></h2> | |||
*[[Harmer_Lab:Stacey_Harmer|Stacey Harmer]] | *[[Harmer_Lab:Stacey_Harmer|Stacey Harmer]] | ||
*Hagop Atamian | *Hagop Atamian | ||
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*[[User:Akiva Shalit-Kaneh|Akiva Shalit-Kaneh]] | *[[User:Akiva Shalit-Kaneh|Akiva Shalit-Kaneh]] | ||
<h3><font style="color:#CA1F7B;">Former Members</font></ | <h3><font style="color:#E30B5C;">Undergrad & high school interns</font></h3> | ||
*[ | |||
*[http:// | *Dalena (Nhu) Chu | ||
*[ | *Emma Goguen | ||
*[ | *Navdeep Kaur | ||
*[http://www. | *Rohan Konnur | ||
* | *Kellie Sluga | ||
*[http://www. | *Winnifred Toy | ||
*Timothy Youngblood | |||
* | *Michael Zook | ||
<h2><font style="color:#CA1F7B;">Former Members</font></h2> | |||
*[http://www.mpipz.mpg.de/tsuda/members Shajahan_Anver] | |||
*[http://mfcovington.github.io/ Mike Covington] | |||
*[http://www.mofo.com/people/e/ellison-cory Cory Ellison] | |||
*[http://sites.duke.edu/benfey/people/ Polly (Yingshan) Hsu] | |||
*[http://www.joneslab.co.uk/ Matt Jones] | |||
* Ellen Martin-Tryon | |||
*[http://www.linkedin.com/pub/dir/Reetika/Rawat Reetika Rawat] | |||
*Ivan Salles Santos | |||
*Koby Schwartz | *Koby Schwartz | ||
*[ | *[http://www.cragenomica.es/staff/detail/nozomu-takahashi Nozomu Takahashi] | ||
*Mikayala Waugh | *Mikayala Waugh | ||
* | * Brian Williams | ||
*[[Undergrad Alumni]] | *[[Undergrad Alumni]] | ||
|} | |} | ||
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< | <h2><font style="color:#DB7093">Funding</font></h2> | ||
*[http://www.nigms.nih.gov/Research/ National Institute of General Medical Sciences] | *[http://www.nigms.nih.gov/Research/ National Institute of General Medical Sciences] | ||
**[[Harmer_Lab:NIH | Molecular analysis of ''Arabidopsis'' circadian regulation]] | **[[Harmer_Lab:NIH | Molecular analysis of ''Arabidopsis'' circadian regulation]] | ||
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< | <h2><font style="color:#1E90FF;">Recent Publications</font></h2> | ||
*Anver, S., Roguev, A., Zofall, M., Krogan, N.J., Grewal, S.I.S., and Harmer, S.L. (2014) Yeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts. EMBO reports. pii: e201438902. [http://onlinelibrary.wiley.com/doi/10.15252/embr.201438902/abstract] | *Anver, S., Roguev, A., Zofall, M., Krogan, N.J., Grewal, S.I.S., and Harmer, S.L. (2014) Yeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts. EMBO reports. pii: e201438902. [http://onlinelibrary.wiley.com/doi/10.15252/embr.201438902/abstract] | ||
*Hsu, P.Y. and Harmer, S.L. (2013) Wheels within wheels: the plant circadian system. Trends in Plant Science [http://dx.doi.org/10.1016/j.tplants.2013.11.007] | *Hsu, P.Y. and Harmer, S.L. (2013) Wheels within wheels: the plant circadian system. Trends in Plant Science [http://dx.doi.org/10.1016/j.tplants.2013.11.007] | ||
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< | <h2><font style="color:#008000;">Collaborators</font></h2> | ||
[http://people.virginia.edu/~bkb2f/Blackman_Lab/Welcome.html Blackman Lab] | [http://people.virginia.edu/~bkb2f/Blackman_Lab/Welcome.html Blackman Lab] | ||
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[http://www.joneslab.co.uk/ Jones Lab] | |||
<br/> | <br/> | ||
[http://www.mcb.ucdavis.edu/faculty-labs/lagarias/ Lagarias Lab] | [http://www.mcb.ucdavis.edu/faculty-labs/lagarias/ Lagarias Lab] |
Revision as of 20:51, 29 July 2014
Room 2123 |
Announcements
|
ResearchMany organisms, including some prokaryotes and most eukaryotes, possess an internal timer or circadian clock that allows them to regulate their physiology to better adapt to our continually changing world. These circadian clocks generate roughly 24 hour rhythms in physiology and behavior that are maintained even in the absence of environmental cues. Although the molecular components of circadian clocks are not conserved across higher taxa, in all organisms studied these clocks are cell autonomous oscillators and in diverse eukaryotes are composed of complex transcriptional networks.
As rooted organisms living in a continually changing world, plants are masters at withstanding environmental variation. The circadian clock is key: it both ensures the optimal timing of daily and seasonal events to cope with predictable stresses and regulates myriad signaling pathways to optimize responses to environmental cues. The study of circadian rhythms in plants thus presents a wide range of fascinating questions with real-world applications: What is the molecular nature of the circadian clock; that is, how can a cell keep time? What aspects of physiology are under circadian regulation? What are the mechanistic links between the clock network and other signaling pathways? Why does a functional circadian clock provide an adaptive advantage?
The Harmer lab is using Arabidopsis thaliana and sunflower to address these important questions. We use forward and reverse genetics, genomics, biochemistry, and physiological studies to better understand the nature of the plant clock and how it helps shape plant responses to the environment.
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Lab Members
Undergrad & high school interns
Former Members
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Funding |
Recent Publications
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CollaboratorsBlackman Lab
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http://www2.clustrmaps.com/stats/maps-no_clusters/openwetware.org-wiki-Harmer_Lab-thumb.jpg |