Gleissner

PD Dr. med. Christian A. Gleisner

Department of Cardiology, Angiology and Pneumonology
Consulting Physician
University of Heidelberg
Im Neuenheimer Feld 410
69120 Heidelberg
Germany

christian.gleissner@med.uni-heidelberg.de

Tel: +49(0)6221-568676
Fax: +49(0)6221-565515

School and University

2002 Graduation from Medical School (grade 1.6)
2001-2002 Final Year Electives at Harvard Medical School, University of Toronto, Institute of Neurology/University College London
1995-2002 School of Medicine, University of Heidelberg, Germany

Clinical Education

2016 Accreditation "Hypertension Specialist" by the German Hypertension League
2015 Accreditation "Interventional Cardiologist" by the German Cardiac Society
2011 Board Exam Internal Medicine and Cardiology
2002-2011 Resident, Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)

Clinical Leadership Competence

2015-present Head of the Cardiology Day Unit, Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)
2014-present Member of the Coronary Catheter 24 Hour Emergency Team
2014-2015 Head of the Cardiology Intermediate Care Unit, Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)
2012-2014 Head of the Cardiology Private Ward Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)
2011-2013 Head of Cardiology outpatient clinics, Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)

Clinical Expertise

Invasive cardiology
• Coronary angiography (approx. 4000 procedures)
• Percutaneous coronary interventions including stent implantation (approx. 1500 procedures)
• Fractional flow reserve, coronary flow reserve studies
• Right heart catheterization (approx. 1000 procedures)
• Transseptal puncture (approx. 200 procedures)
• Pulmonary vascular resistance studies with NO or prostaglandin challenge (approx. 1000 procedures)
• Right or left ventricular biopsy (approx. 1000 procedures)
Non-invasive cardiology
• Coronary artery disease, heart failure in-/outpatient care (>10 years experience)
• Cardiovascular intensive treatment unit (several years experience)
• Echocardiography (2000), transesophageal echocardiography (200), stress echocardiography (300)
• Cardiopulmonary exercise testing
• Pacemaker management (uni-/biventricular, ICD)

Science

2013 "Habilitation“ (highest academic qualification before becoming full professor): „Differentiation and heterogeneity of macrophages in human atherosclerosis“, Medical Faculty of the University of Heidelberg

2009-present Research group leader, Department of Cardiology, University of Heidelberg, Heidelberg, Germany (Chairman: Hugo A. Katus, MD)
2007-2009 Research Associate, La Jolla Institute for Allergy & Immunology, Division of In-flammation Biology, La Jolla/California (Head: Klaus Ley, MD)
2006-2007 Research Associate, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville/Virginia (Head: Klaus Ley, MD)
2002 Doctoral degree, Medical Faculty of the University of Heidelberg, Germany, “Extended experience and subgroup analysis using cardiac troponin T for rejection monitoring after heart transplantation” (grade “magna cum laude”)

Teaching

2002-present Bedside teaching and seminars for medical students (Heidelberger Curriculum Medicinale HeiCuMed)
2006-2009 Supervision of undergraduate and graduate students in the lab
2009-present Supervision of doctoral students (M.D. thesis)
2012 Didactics Training (Center for Didactics in Academics Baden-Württemberg)

Grants and Awards

2016 Else Kröner-Fresenius Stipend, €287.000 (Co-Investigator)
2016 Rudi-Busse-Young Investigator Award of the German Cardiac Society, €1.500 (Principal Investigator)
2015 Ernst und Berta Grimmke Stipend, €51.000 (Principal Investigator)
2014 Oskar Lapp Stipend by the German Heart Foundation, €25.000 (Principal Investigator)
2013 Otto Hess Stipend for doctoral students by the German Heart Foundation, €6.000 (Principal Investigator)
2012-2013 Stipend by the German Heart Foundation, €34.000
2011 Kaltenbach Stipend for doctoral students by the German Heart Foundation, €6.000 (Principal Investigator)
2011-present Fellow of the German Academy of Metabolism (supported by Roche)
2010-2012 Innovationsfonds FRONTIER (University of Heidelberg), €120.000
2007 Participant 57th Meeting of Nobel Laureates in Lindau, Germany
2006 Research Scholarship (German Research Foundation), €60.000
2004 Research Fellowship Award (International Society for Heart and Lung Transplantation), $40.000
2002 Young Medical Investigator Award (University of Heidelberg, Germany), €60.000

Memberships

• European Society of Cardiology (Working Group on Atherosclerosis and Vascular Biology)
• German Cardiac Society (Founding Member Working Group ‘German Chapter of Young Cardiologists’, Working Group on Atherosclerosis and Vascular Biology)
• German Atherosclerosis Society (Member of Scientific Board)
• German Academy of Metabolism
• German Society for Internal Medicine

Reviewer

Reviewer (Journals): American Journal of Transplantation, Arteriosclerosis, Thrombosis and Vascular Biology, Atherosclerosis, Circulation, European Heart Journal, European Journal of Immunology, Innate Immunity, Journal of Cellular and Molecular Medicine, Journal of Thrombosis and Haemostasis, Journal of Immunology, Kidney International, Nature Communications, PLOS One, Thrombosis and Haemostasis
Reviewer (Scientific Societies): American Heart Association (Scientific Sessions), British Heart Foundation, German Research Foundation, Netherlands Organisation for Scientific Research

Original papers

- Mosch, J., Gleissner, C.A., Body, S., Aikawa, E. 2016. Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus. Histol Histopathol, 11797.

- Gleissner, C.A., Erbel, C., Linden, F., Domschke, G., Akhavanpoor, M., Doesch, A.O., Buss, S.J., Giannitsis, E., Katus, H.A., Korosoglou, G. 2016. Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology. Atherosclerosis, 251:94-100.

- Rivinius, R., Helmschrott, M., Ruhparwar, A., Schmack, B., Karck, M., Erbel, C., Gleissner, C.A., Akhavanpoor, M., Frankenstein, L., Darche, F.F., Schweizer, P.A., Scholz, E., Zitron, E., Thomas, D., Friedrich, J., Ehlermann, P., Bruckner, T., Katus, H.A:, Doesch, A.O. 2016. The influence of surgical anastomosis on early post transplant atrial fibrillation – Comparison of biatrial, bicaval, and total orthotopic heart transplantation. Drug Des Devel Ther, 10:677-86.

- Erbel, C., Korosoglou, G., Ler, P., Akhavanpoor. M., Domschke, G., Linden, F. Doesch, A.O., Buss, S.J. Giannitsis, E., Katus, H.A., Gleissner, C.A. 2015 CXCL4 plasma levels are not associated with the extent of coronary artery disease or with coronary plaque morphology. PLoS One, 10(11):e0141693.

- Erbel, C., Wolf, A., Lasitschka, F., Linden, F., Domschke, G., Akhavanpoor, M., Doesch, A.O., Katus, H.A., Gleissner, C.A. 2015 Prevalence of M4 macrophages within human coronary atherosclerotic plaques is associated with features of plaque instability. Int J Cardiol, 186:219-225.

- Helmschrott, M., Rivinius, R., Ruhparwar, A., Schmack, B., Erbel, C., Gleissner, C.A., Akhavanpoor, M., Frankenstein, L., Ehlermann, P., Bruckner, T., Katus, H.A., Doesch, A.O. 2015. Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation. Drug Des Devel Ther, 9:1217-24.

- Rivinius, R., Helmschrott, M., Ruhparwar, A., Schmack, B., Klein, B., Erbel, C., Gleissner, C.A., Akhavanpoor, M., Frankenstein, L., Darche, F.F., Thomas, D., Ehlermann, P., Bruckner, T., Katus, H.A., Doesch, A.O. 2014. Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy. Drug Des Devel Ther, 9:93-102.

- Akhavanpoor, M.*, Gleissner, C.A.*, Gorbatsch, S., Doesch, A.O., Akhavanpoor. H., Wangler, S., Jahn, F., Lasitschka, F., Katus, H.A., Erbel, C. 2014. CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions. Drug Des Devel Ther, 8:2359-71. * Equal contribution.

- Erbel, C., Akhavanpoor, M., Okuyucu, D., Wangler, S., Dietz, A., Zhao, L., Stellos, K., Little, K.M., Lasitschka, F:, Doesch, A., Hakimi, M., Dengler, T.J., Giese, T., Blessing, E., Katus, H.A., Gleissner, C.A. 2014. IL-17A influences essential functions of the monocyte / macrophage lineage and is involved in advanced murine and human atherosclerosis. J Immunol, 193:4344-55.

- Helmschrott, M., Beckendorf J., Akyol, C., Ruhparwar, A., Schmack, B., Erbel, C., Gleissner, C.A., Akhavanpoor M, Ehlermann, P., Bruckner, T., Katus, H.A., Doesch, A.O. 2014. Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen. Drug Des Devel Ther, 8:1307-14.

- Gleissner, C.A., Erbel, C., Haeussler, J., Akhavanpoor, M., Domschke, G., Linden, F., Doesch, A.O., Conradson, G., Buss, S.J., Hofmann, N.P., Gitsioudis, G., Katus, H.A. Korosoglou, G. 2014. Low levels of natural IgM antibodies against phosphorylcholine are independently associated with vascular remodeling in patients with coronary artery disease. Clin Res Cardiol, 104:13-22.

- Doesch, A.O., Zhao, L., Gleissner, C.A., Akhavanpoor, M., Rohde, D., Okuyucu, D., Hakimi, M., Dengler, T.J., Katus, H.A., Erbel, C. 2014. Inhibition of B7-1 (CD80) by RhuDex(®) reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions. Drug Des Devel Ther, 8:447-57.

- Erbel, C., Okuyucu, D., Akhavanpoor, M., Zhao, L., Wangler, S., Hakimi, M., Doesch, A., Dengler, T.J., Katus, H.A., Gleissner, C.A. 2014. A human ex vivo atherosclerotic plaque model to study lesion biology. J Vis Exp, (87).

- Shaked, I., Hanna, D.B., Gleißner, C., Marsh, B., Plants, J., Tracy, D., Anastos, K., Cohen, M., Golub, E.T., Karim, R., Lazar, J., Prasad, V., Tien, P.C., Young, M.A., Landay, A.L., Kaplan, R.C., Ley, K. 2014. Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. Arterioscler Thromb Vasc Biol, 34(5):1085-92.

- Erbel, C., Tyka, M., Helmes, C.M., Akhavanpoor, M., Rupp, G., Domschke, G., Linden, F., Wolf, A., Doesch, A., Lasitschka, F., Katus, H.A., Gleissner, C.A. 2014. CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7+S100A8+ in vitro and in vivo. Innate Immunity, 21:255-65.

- Kraeuter, M., Helmschrott, M., Erbel, C., Gleissner, C.A., Frankenstein, L., Schmack, B., Ruhparwar, A., Ehlermann, P., Katus, H.A., Doesch, A.O. 2013. Conversion to generic cyclosporine A in stable chronic patients after heart transplantation. Drug Des Devel Ther, 7:1421-6.

- Cornu, C., Dufays, C., Gaillard, S., Gueyffier, F., Redonnet, M., Sebbag, L., Roussoulières, A., Gleissner, C.A., Groetzner, J., Lehmkuhl, H.B., Potena, L., Gullestad, L., Cantarovich, M., Boissonnat, P. Impact of the Reduction of Calcineurin Inhibitors on Renal Function in Heart Transplant Patients: A Systematic Review and Meta-Analysis. 2013. Br J Clin Pharmacol, 78:24-32.

- Kraeuter, M., Helmschrott, M., Erbel, C., Gleissner ,C.A., Frankenstein, L., Schmack, B., Ruhparwar, A., Ehlermann, P., Katus, H.A., Doesch, A.O. 2013. Conversion to generic cyclosporine A in stable chronic patients after heart transplantation. Drug Des Devel Ther, 7:1421-6.

- Doesch, A.O., Mueller, S., Erbel, C., Gleissner, C.A., Frankenstein, L., Hardt, S., Ruhparwar, A., Ehlermann, P., Dengler, T., Katus, H.A. 2013. Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study. Drug Des Devel Ther, 2013 7:1323-8.

- Erbel, C., Rupp, G., Helmes, C.M., Tyka, M., Linden, F., Doesch, A.O., Katus, H.A., Gleissner ,C.A. 2013. An in vitro model to study heterogeneity of human macrophage differentiation and polarization. J Vis Exp. (76).

- Gueler, I., Mueller, S., Helmschrott, M., Oeing, C.U., Erbel, C., Frankenstein, L., Gleissner, C., Ruhpawar, A., Ehlermann, P., Dengler, T.J., Katus, H.A., Doesch, A.O. 2013. Effects of vildagliptin (Galvus ®) therapy in patients with type 2 diabetes mellitus after heart transplantation. Drug Des Devel Ther, 7:297-303.

- Erbel, C., Taskin, R., Doesch, A., Dengler, T.J., Wangler, S., Akhavanpoor, M., Ruhpawar, A., Giannitsis, E., Katus, H.A., Gleissner, C.A. 2013. High sensitive troponin T measurements early after heart transplantation predict shot and long term survival. Transplantation, 26(3):267-72.

- Doesch, A.O., Repp, J., Hofmann, N., Erbel, C. Frankenstein, L., Gleissner, C.A., Schmidt, C., Ruhpawar, A., Zugck, C., Schnitzler, P., Ehlermann, P., Dengler, T.J., Katus, H.A. 2012. Effects of oral Valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients. Drug Des Devel Ther, 6:289-95.

- Korosoglou, G., Gleissner, C.A., Giannitsis, E., Katus, H.A. 2012. Subclinical atherosclerosis and chronic troponin elevation: the voice of silence in diabetics. J Am Coll Cardiol, 60(2):167-8.

- Erbel, C., Achenbach, J., Dengler, T.J., Lasitschka, F., Gleissner, C.A., Bea, F., Katus, H.A., Szabo, G. 2011. PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels. Eur J Med Res, 16(8):367-74.

- Erbel, C., Dengler, T.J., Wangler, S., Bea, F. Wambsganss, N., Hakimi, M., Böckler, D., Katus, H.A., Gleissner, C.A. 2010. Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability. Basic Res Cardiol, 106(1), 125-34.

- Gleissner, C.A., Little, K.M., Ley, K. 2010. CXCL4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol, 184 (9), 4810-8.

- Schulz, C., Heuschen, N.V., Fröhlich, T., Lorenz, M., Pfeiler, S., Gleissner, C.A., Kremmer, E., Kessler, M., Khandogau A.G., Engelmann, B., Ley, K., Massberg, S., Arnold, G.J. 2010. Identification of novel downstream targets of platelet glycoprotein VI activation. Blood, 115(20):4102-10.

- Gleissner, C.A., Shaked, I., Erbel, C., Böckler, D., Katus, H.A., Ley, K. 2010. CXCL4 induces CD163- macrophages: Functional implication in atherosclerosis. Circ Res, 106(1):203-11.

- Konstandin, M.H., Doesch, A., Ammon, K., Wabnitz, G.H., Gleissner, C.A., Koch, A., Remppis, A., Katus, H.A., Dengler, T.J. 2008. Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy. Clin Transplant, 22(5):639-44.

- Gleissner, C.A., Sanders, J.M., Nadler, J.L., Ley, K. 2007. Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol, 28(6):1137-43.

- Cho, H.J., Shashkin, P., Gleissner, C.A., Dunson, D., Jain, N., Lee, J., Miller, Y., Ley, K. 2007. Induction of dendritic cell-like phenotype in macrophages during foam cell formation. Physiol Genomics, 29(2):149-160.

- Gleissner, C.A., Zastrow, A., Klingenberg, R., Kluger, M.S., Konstandin, M., Celik, S., Haemmerling, S., Shankar, V., Giese, T., Katus, H.A., Dengler, T.J. 2007. IL-10 inhibits endothelium-dependent T-cell costimulation by upregulation of ILT3/4 in human vascular endo-thelial cells. Eur J Immunol, 37(1):177-192.

- Gleissner, C.A., Doesch, A., Ehlermann, P., Koch, A., Sack, F.U., Katus, H.A., and Dengler, T.J. 2006. Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy. Am J Transplant, 6(11):2750-2758.

- Gleissner, C.A., Klingenberg, R., Staritz, P., Koch, A., Ehlermann, P., Wiggenhauser, A., and Dengler, T.J. 2006. Role of erythropoietin in anemia after heart transplantation. Int J Cardiol 112(3):341-347.

- Klingenberg, R., Gleissner, C., Koch, A., Schnabel, P.A., Sack, F.U., Zimmermann, R., Katus, H.A., and Dengler, T.J. 2005. Impact of pre-operative diabetes mellitus upon early and late survival after heart transplantation: a possible era effect. J Heart Lung Transplant 24(9):1239-1246.

- Klingenberg, R., Autschbach, F., Gleissner, C., Giese, T., Wambsganss, N., Sommer, N., Richter, G., Katus, H.A., and Dengler, T.J. 2005. Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro. Eur J Immunol 35(6):1712-1721.

- Klingenberg, R., Koch, A., Gleissner, C., Schnabel, P.A., Haass, M., Remppis, A., Katus, H.A., and Dengler, T.J. 2005. Determinants of B-type natriuretic peptide plasma levels in the chronic phase after heart transplantation. Transpl Int 18(2):169-176.

- Gleissner, C.A., Murat, A., Schafer, S., Klingenberg, R., Koch, A., Remppis, A., Zimmermann, R., Katus, H.A., and Dengler, T.J. 2004. Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal function. Transplantation 77(5):710-717.

- Gleissner, C.A., Klingenberg, R., Nottmeyer, W., Zipfel, S., Sack, F.U., Schnabel, P.A., Haass, M., and Dengler, T.J. 2003. Diagnostic efficiency of rejection monitoring after heart transplantation with cardiac troponin T is improved in specific patient subgroups. Clin Transplant 17(3):284-291.

- Gleissner, C.A., Zehelein, J., Sack, F.U., Schnabel, P., Haass, M., and Dengler, T.J. 2002. Extended experience and subgroup analysis using cardiac troponin T for rejection monitoring after heart transplantation. Transplant Proc 34(6):2178-2180.

Reviews and Editorials

- Gleissner, C.A. 2016. Translational atherosclerosis research: From experimental models to coronary artery disease in humans. Atherosclerosis, 248:110-6.

- Linden, F., Domschke, G., Erbel, C., Akhavanpoor, M., Katus, H.A., Gleissner. C.A. 2014. Inflammation in coronary atherosclerosis – from molecular biology to clinical application. Front Physiol, 5:455.

- Akhavanpoor M., Wangler S., Gleissner C.A., Korosoglou G., Katus H.A., Erbel C. 2014. Adventitial inflammation and its interaction with intimal atherosclerotic lesions. Front Physiol, 5:296.

- Gleissner, C.A. 2012. Platelet-derived chemokines in atherosclerosis – what´s new? Curr Vasc Pharmacol, 10(5):563-9.

- Gleissner, C.A. 2012. Macrophage phenotype modulation by platelet factor-4 in vascular disease. Front Vasc Biol, 2012;3:1.

- Sperandio, M., Gleissner, C.A., Ley, K. 2009. Glycosylation in immune cell trafficking. Immunol Rev, 230(1):97-113.

- Gleissner, C.A., Dengler T.J. 2009. Induction of ILT expression on non-professional APC: Clinical Applications. Human Immunol, 70(5):357-9.

- Gleissner, C.A., von Hundelshausen, P., Ley, K. 2008. Chemokines and platelet functions in vascular disease. Arterioscler Thromb Vasc Biol, 28(11):1920-1927.

- Gleissner, C.A., Galkina E., Nadler J.L., Ley, K. 2008. Mechanisms by which diabetes increases cardiovascular disease. Drug Discovery Today: Disease Mechanisms, 4(3):131-140.

- Gleissner, C.A., Ley, K. 2007. CXCL4 in atherosclerosis: possible role in monocyte arrest and macrophage foam cell formation. Thromb Haemost, 98(5):917-918.

- Gleissner, C.A., Leitinger, N., Ley, K. 2007. Effects of native and modified low density lipoprotein on monocyte recruitment in atherosclerosis. Hypertension, 50(2):276-283.

- Dengler, T.J., Gleissner, C.A., Klingenberg, R., Sack, F.-U., Schnabel, P.A., Katus, H.A. 2007. Biomarkers after heart transplantation – non-genomic. Heart Failure Clinics, 3(1):69-81.

Book chapters

- Gleissner, C.A., Erbel C., Katus, H.A. CXCL4 (Platelet factor-4) inhibits foam cell formation in human macrophages. In: Annual Meeting of the German Atherosclerosis Society 2011. ISBN 978-3-936423-09-9.

- Gleissner, C.A., Erbel, C. CXCL4-induced macrophages: A novel therapeutic target in human atherosclerosis? In: Atherogenesis, InTech – Open Access Publisher, Rijeka, Croatia, 2011.ISBN 978-953-307-992-9.

- Gleissner, C.A. Understanding macrophage heterogeneity in human atherosclerosis – the key to treating cardiovascular disease? In: Research Advances in circulation research, Global Research Network, Kerala, India, 2011.

Media

- Radio: https://www.klinikum.uni-heidelberg.de/fileadmin/pressestelle/podcasts/2016/2016_0211_Campus_UKH_Herz_unter_Stress.mp3
- Television: http://www.swr.de/odysso/frauenherzen-sind-anders/-/id=1046894/did=16790274/nid=1046894/ochash/index.html
- Expertscape: http://expertscape.com/au/atherosclerosis/Gleissner%2C+C+A
(external links, 8 November 2016)