Giet:Research: Difference between revisions
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The mitotic spindle plays also a crucial role in polarized stem cells to define the plan of cell division and thus to segregate unequally cell fate determinants in the future daughter cells. This process is important for tissue homeostasis and may be the cause of tumor formation. Indeed, mitotic spindle orientation failure along the apico-basal axis triggers missegregation of cortical cell fates and overproliferation (fig.2). Thus, a better understanding of the regulation of the microtubule network regulation by Microtubule Associated proteins (MAPS) would therefore constitute an important advance in order to understand the relationships between mitotic spindle morphogenesis and cancer. | The mitotic spindle plays also a crucial role in polarized stem cells to define the plan of cell division and thus to segregate unequally cell fate determinants in the future daughter cells. This process is important for tissue homeostasis and may be the cause of tumor formation. Indeed, mitotic spindle orientation failure along the apico-basal axis triggers missegregation of cortical cell fates and overproliferation (fig.2). Thus, a better understanding of the regulation of the microtubule network regulation by Microtubule Associated proteins (MAPS) would therefore constitute an important advance in order to understand the relationships between mitotic spindle morphogenesis and cancer. | ||
<gallery widths=400px heights=200px perrow=0 center | |||
Image:SpindleGiet.jpg|Fig.1: The mitotic spindle is required for chromosome segregation | |||
Image:Asymdivgiet.jpg|Fig.2: The mitotic spindle is required to segregate cell fate determinants. | <gallery widths=400px heights=200px perrow=0 > | ||
|align=center | |||
Image:SpindleGiet.jpg|[[Media:SpindleGiet.jpg|Fig.1: The mitotic spindle is required for chromosome segregation.]] | |||
Image:Asymdivgiet.jpg|[[Media:Asymdivgiet.jpg|Fig.2: The mitotic spindle is required to segregate cell fate determinants.]] | |||
</gallery> | </gallery> | ||
Revision as of 02:19, 11 July 2014
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The mitotic spindle is a microtubule-based machine required for equal chromosome segregation, a key role to maintain genome stability. Spindle assembly defect causes mitotic delay or cell death. Therefore interference with spindle assembly and activation of the spindle checkpoint is widely used as a strategy to inhibit (cancer) cell division (fig.1). The mitotic spindle plays also a crucial role in polarized stem cells to define the plan of cell division and thus to segregate unequally cell fate determinants in the future daughter cells. This process is important for tissue homeostasis and may be the cause of tumor formation. Indeed, mitotic spindle orientation failure along the apico-basal axis triggers missegregation of cortical cell fates and overproliferation (fig.2). Thus, a better understanding of the regulation of the microtubule network regulation by Microtubule Associated proteins (MAPS) would therefore constitute an important advance in order to understand the relationships between mitotic spindle morphogenesis and cancer.
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