Gao lab:Publications

Biomaterials & Drug Delivery Lab

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Publications

Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao. "In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy". J. Control. Release 2016, 237, 71-77. Note: This paper has been highlighted by Tsinghua University News.

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Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao. "Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy". Biomaterials 2016, 96, 84-92. Note: This paper has been highlighted by Tsinghua University News.

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Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao. "Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer". Nanoscale 2016, 8, 4452-4457.

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Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao. "Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha". Adv. Mater. 2015, 27, 320-7324.  Note: This paper has been highlighted by Science China Materials and Tsinghua University News.

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Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao. "Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification". Biomaterials 2015, 64, 2-9. Note: This paper has been highlighted by Tsinghua University News.

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Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao. "Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects". Chem. Commun. 2015, 51, 11405-11408.

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Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao. "Synthesis of well-defined protein-polymer conjugates for biomedicine". Polymer 2015, 66, A1-A10. 

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Liao Peng, Huijuan Zhang, Anchao Feng, Meng Huo, Zilin Wang, Jin Hu, Weiping Gao and Jinying Yuan. "Electrochemical redox responsive supramolecular self-healing hydrogels based on host-guest interaction". Polym. Chem. 2015, 6, 3652-3659.

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Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao. "Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention". Biomaterials 2015, 47, 13-19.

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Bo-wen Liu, Hang Zhou, Si-tong Zhou, Hui-juan Zhang, An-chao Feng, Chun-mei Jian, Jin Hu, Wei-ping Gao, Jin-ying Yuan. "Synthesis of Self-Assembly of CO2-Temperature Dual Stimuli-Responsive Triblock Copolymers”, Macromolecules 2014, 47, 2938-2946.

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Liao Peng, Anchao Feng, Huijuan Zhang, Hong Wang, Chunmei Jian, Bowen Liu, Weiping Gao, Jinying Yuan. “Votage-responsive micelles based on the assembly of two biocompatible homopolymers”, Polym. Chem. 2014, 5, 1751-1759.

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Yizhi Qi, Miriam Amiram, Weiping Gao, Dewey McCafferty, and Ashutosh Chilkoti. “Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein”, Macromol. Rapid Commun. 2013, 34, 1256-1260.

Before 2012

Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti. “In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide”, Polym. Chem., 2011, 2, 1561-1566.

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Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti. “In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation”, Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437. Note: This paper has been highlighted by Nature and Science-Business eXchange (SciBX).

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Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti. “In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics”, Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236. Note: This paper has been highlighted by media and journals such as Nature, Science Daily, and Science-Business eXchange(SciBX).

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Yoshinobu Tsujii, Akihiro Nomura, Kenji. Okayasu, Weiping Gao, Kohji Ohno, Takeshi Fukuda. “AFM studies on microtribology of concentrated polymer brushes in solvents” Journal of Physics: Conference Series 2009, 184, 012031.

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Yu Bai, Weiping Gao, Jingjing Yan, Yuguo Ma, Dehai Liang, Zichen Li, Bingyong Han, Wantai Yang, Erqiang Chen. “Co-aggregation process of poly(ethylene oxide)-b-polybutadiene/poly(acrylic acid) based on evolution of interpolymer hydrogen bonding in solutions” Polymer 2008, 49, 2099-2106.

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Weiping Gao, Yu Bai, Erqiang Chen, Zichen Li, Bingyong Han, Wantai Yang, Qifeng Zhou. “Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution” Macromolecules 2006, 39, 4894-4898.

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Book Chapters

Xinyu Liu, Weiping Gao. “Antibody-Drug Conjugates” Chapter 6 in Biomedical Nanomaterials (eds Y. Zhao and Y. Shen)(2016), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.

Patents

高卫平、胡瑾、王贵林，融合蛋白IFN-ELP及其应用，2016.07，中国，PCT/CN2016/089739

高卫平、孙蒙蒙，类弹性蛋白多肽温度响应性纳米材料及其制备方法与应用，2016.05，中国，201610318098.4

高卫平、胡瑾、王贵林，干扰素高分子结合体IFN-PMPC的制备及其应用， 2016.03，中国，201610169447.0

高卫平，胡瑾，王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法， 2015.09，PCT/CN2015/097684

高卫平，胡瑾，王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法，2015.10，中国，201510742013.0

高卫平，胡瑾，王贵林. 融合蛋白IFN-ELP及其应用，2015.10，中国，201510471041.3

高卫平，胡瑾，王贵林. 蛋白质-高分子结合体及其制备方法，2014.09，中国，201410478802.3

高卫平，张立彬. 抗体-高分子结合体、其荧光衍生物及它们的制备方法，2014.09，中国，201410480011.4 

Ashutosh Chilkoti, Weiping Gao. “Biomolecule polymer conjugates and methods for making the same”, Date of Patent: Jul. 30, 2013, Patent No.: US8497356B2