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| [[Ruixin | <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] | | [[Zhu_Lab | <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] |
| [[Ruixin:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] | | [[Zhu_Lab:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] |
| [[Ruixin:Back Door | <font face="trebuchet ms" style="color:#ffffff"> '''Internal''' </font>]] | | [[Zhu_Lab:Back Door | <font face="trebuchet ms" style="color:#ffffff"> '''Internal''' </font>]] |
| [[Ruixin:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] | | [[Zhu_Lab:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] |
| [[Ruixin:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] | | [[Zhu_Lab:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] |
| [[Ruixin:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] | | [[Zhu_Lab:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] |
| [[Ruixin:Talks | <font face="trebuchet ms" style="color:#ffffff"> '''Talks''' </font>]] | | [[Zhu_Lab:Talks | <font face="trebuchet ms" style="color:#ffffff"> '''Talks''' </font>]] |
| [[Ruixin:Position Available | <font face="trebuchet ms" style="color:#ffffff"> '''Position Available ''' </font>]] | | [[Zhu_Lab:Position Available | <font face="trebuchet ms" style="color:red"> '''Position Available''' </font>]] |
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| [[Image:DSCF3817.png|150px]] | | [[Image:DSCF3817.png|150px]] |
| | '''Lixin ZHU''' '''Ph.D.''' |
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| Assistant Professor, Director, Research Laboratory, Digestive Disease and Nutrition Center, | | Assistant Professor, Director, Research Laboratory, Digestive Disease and Nutrition Center, |
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| 3435 Main Street, 422 BRB, Buffalo, NY14214 | | 3435 Main Street, 422 BRB, Buffalo, NY14214 |
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| | (716) 829-2191 (Office), (716) 829-2192 (Lab), (716) 829-3585 (Fax) |
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| (716) 829-2191 (Office), (716) 829-2192 (Lab), (716) 829-3585 (fax), (510) 418-8754 (cell),
| | [lixinzhu@buffalo.edu] [http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=lixinzhu'''Faculty web page'''] [http://pedsgiwny.com/'''Lab web page'''] |
| | | ---- |
| lixinzhu@buffalo.edu | | '''GI Research laboratory''' is located in the Biomedical Research Building (BRB) of the University at Buffalo - SUNY, South Campus, a relatively new, well equipped research |
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| = Education =
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| 1995,9-2001,8Shanghai Institute of Biochemistry, the Chinese Academy of Sciences.
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| Ph. D. obtained in August 2001.
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| Mentor: Prof. Guangdi Li
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| Projects: Molecular biology of hepatitis C virus (HCV). Development of an evaluation system for HCV vaccine. Development of a live viral vaccine against HCV.
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| 1991,9-1995,7Department of biochemistry and molecular biology, Nankai University, China
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| bachelor’s degree of science, June, 1995. '''Graduated with honor.'''
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| Mentor: Professor Shufang Wang
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| Project: Effect of agrobacterium tumefacients elicitors on the accumulation of indole alkaloids in catharanthus roseus calli
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| '''''Working experience'''''
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| 2009,2-Assistant professor, Director of GI Laboratory, Digestive Disease and Nutrition Center, University at Buffalo, State University of New York
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| 2003,7-2009,1Postdoctoral fellow, Department of molecular and cell biology,
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| University of California, Berkeley.
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| Mentor: Prof. John G. Forte
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| Projects: Ezrin function in gastric parietal cells, renal proximal tubule cells and small intestine enterocytes: phosphorylation regulation on ezrin conformation and activity. SNARE proteins in gastric parietal cells.
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| 2002,8-2003,7Postdoctoral fellow, Department of molecular and cell biology,
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| University of California, Berkeley.
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| Mentor: Prof. Hsiao-Ping Moore
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| Project: The constitutive-like secretory pathway of protein secretion from immature secretory granule in pituitary cells.
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| 2001,8-2002,8Assistant researcher, Shanghai Institute of biochemistry and cell biology, the Chinese Academy of Sciences.
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| Mentor: Prof. Yuan Wang
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| Projects: Development of a DNA vaccine against HCV. Induction of apoptosis by HCV E2.
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| 1999,5-2000,10Visiting scientist, Institute of Molecular Virology, National research center of environment and health, Munich, Germany.
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| PI: Dr. Gerd Sutter
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| Project: Development of a live viral vaccine against HCV.
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| '''''Honors and awards'''''
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| 2009- Invited as Pre-reviewer, the World Journal of Gastroenterology.
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| 2008 Takeda Research Award, the American Physiological Society.
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| 2007-2008Invited as Science News Editor, the World Journal of Gastroenterology.
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| 1999-2000Fellowship for visiting scholars, from the International Bureau of the BMBF, Germany.
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| 1995-2001Fellowship from Shanghai Institute of Biochemistry, the Chinese Academy of Sciences.
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| 1991-1992First-class scholarship for excellent students, NanKai University.
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| '''''Grant'''''
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| In 2001, obtained a grant titled "'''''Development of a recombinant vaccine against hepatitis C virus (HCV): recombinant MVA-HCV live vaccine and combinational rMVA and DNA vaccine'''''" from the National 863 High Technology Project of China (No. 863-102-07-02-02).
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| '''''Patents (one invention applied in different countries)'''''
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| # Recombinant MVA capable of expressing structural HCV antigens. Inventors: Sutter G, Erfle V, Wang Y, Li G, '''Zhu L''', Staib C. United States Patent 20050019347; Kind Code: A1. [http://www.freepatentsonline.com/20050019347.html http://www.freepatentsonline.com/20050019347.html]
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| # Recomninantes MVA mit der Faehigheit zur Expression von HCV Struktur-Antigenen. German patent.
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| [http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP1423525 http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP1423525] | |
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| = Peer reviewed publications (Cited 81 times in total by April, 2008) =
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| # '''Lixin Zhu''', Jason Hatakeyama, Bing Zhang, Joy Makdisi, Cody Ender, and John G. Forte, 2009, Novel insights of the gastric gland organization revealed by chief cell specific expression of moesin. ''Am J Physiol Gastrointest Liver Physiol.'' 296:G185-95.'' ''
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| # '''Lixin Zhu''', 2008, Teaching glycoprotein with a classical paper: knowledge and methods in the course of an exciting discovery ---- The story of discovering HK-ATPase -subunit. ''Biochemistry and Molecular Biology Education''. 36:336-340.
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| # '''Lixin Zhu''', Jason Hatakeyama, Cheng Chen, Aditi Shastri, Kevin Poon and John G. Forte, 2008, Comparative study of ezrin phosphorylation among different tissues: more is good; too much is bad. ''Am J Physiol Cell Physiol.'' 295:C192-202.
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| # '''Lixin Zhu''', Rihong Zhou, Shelley Mettler, Tim Wu, Aennes Abbas, Joseph Delaney and John G. Forte, 2007, High turnover of ezrin T567 phosphorylation: conformation, activity and cellular function. ''Am J Physiol Cell Physiol.'' 293:C874-84.
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| # Stephanie Tenhumberg, Bjoern Schuster, '''Lixin Zhu''', Marina Kovaleva, Juergen Scheller, Karl-Josef Kallen and Stefan Rose-John, 2006, gp130 dimerization in the absence of ligand: Preformed cytokine receptor complexes, ''Biochemical and Biophysical Research Communications''. 346:649-657.
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| # Rihong Zhou, '''Lixin Zhu''', Andrew Kodani, Paul Hauser, Xuebiao Yao, John G. Forte, 2005, Phosphorylation of ezrin on threonine 567 produces a change in secretory phenotype and repolarizes the gastric parietal cells, ''Journal of Cell Science''. 118:4381-4391.
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| # Serhan Karvar, '''Lixin Zhu''', James Crothers Jr, Waylan Wong, Mustafa Turkoz, John G. Forte, 2005, Cellular localization and stimulation-associated distribution dynamics of syntaxin-1 and syntaxin-3 in gastric parietal cells, ''Traffic''. 6:1-13.
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| # '''Lixin Zhu''', Yuechueng Liu, John G. Forte, 2005, Ezrin oligomers are the membrane-bound dormant form in gastric parietal cells, ''Am J Physiol Cell Physiol.'' 288:C1242-C1254.
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| # Jing Liu,''' Li-Xin Zhu''', Yu-Ying Kong, Guang-Di Li, Yuan Wang, 2005, Purification and application of C-terminally truncated hepatitis C virus E1 proteins expressed in ''Escherichia coli'', ''World Journal of Gastroenterology''. 11: 503-507.
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| # '''Li-Xin Zhu''', Jing Liu, Ye Ye, You-Hua Xie, Guang-Di Li, Yuan Wang, 2004, A candidate DNA vaccine elicited HCV specific humoral and cellular immune responses, ''World Journal of Gastroenterology''. 10:2488-2492.
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| # '''Li-Xin Zhu''', Jing Liu, You-Hua Xie, Yu-Ying Kong, Ye Ye, Chun-Lin Wang, Guang-Di Li, Yuan Wang, 2004, Expression of hepatitis C virus envelope protein 2 induced apoptosis in cultured mammalian cells, ''World Journal of Gastroenterology.'' 10:2972-2978.
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| # ZHU Jun, WANG Chun-Lin, '''ZHU Li-Xin,''' KONG Yu-Ying, WANG Yuan, LI Guang-Di, 2002, DNA immunization with different recombinant HCV E2 expression plasmids, ''Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Acta Biochemica et Biophysica Sinica).'' 34:445-451''.''
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| # WANG Chun-Lin, '''ZHU Li-Xin''', LIU Jing, ZHANG Zu-Chuan, WANG Yuan, and LI Guang-Di, 2002, Expression and characterization of hepatitis C virus E2 glycoprotein fused to hepatitis B virus preS1(21-47) fragment in CHO cells, ''Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Acta Biochemica et Biophysica Sinica). ''34:400-404.
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| # Jing Liu, Yuying Kong, '''Lixin Zhu''', Yuan Wang and Guangdi Li, 2002, High-level expression of the C-terminal hydrophobic region of HCV E2 protein ectodomain in ''E. coli'', ''Virus genes''. 25:5-13.
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| # '''Li-Xin Zhu''', Jing Liu, Ying-Chun Li, Yu-Ying Kong, Caroline Staib, Gerd Sutter, Yuan Wang, and Guang-Di Li, 2002, Full-length core sequence dependent complex-type glycosylation of hepatitis C virus E2 glycoprotein，''World Journal of Gastroenterology''. 8:499-504.
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| # Jing Liu, '''Lixin Zhu''', Xinxin Zhang, Min Lu, Yuying Kong, Yuan Wang, and Guangdi Li, 2001, Expression, purification, immunological characterization, and application of Escherichia coli-derived hepatitis C virus E2 proteins, Biotechnology and applied biochemistry, 34:109-119.
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| # '''ZHU Li-Xin''', Kong Yu-Ying, WANG Yuan, and LI Guang-Di, 2001, Effect of downstream sequence on the cleavage of envelop protein 1 signal sequence in hepatitis C virus,'' Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Acta Biochemica et Biophysica Sinica)''. 33：682-686.
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| # '''ZHU Li-Xin''', XIE You-Hua, LI Guang-Di, and WANG Yuan, 2001, High frequency of homologous recombination in the genome of modified vaccinia virus Ankara strain (MVA), ''Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Acta Biochemica et Biophysica Sinica)''. 33:497-503.
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| # YANG Li, '''ZHU Li-Xin''', WANG Yuan, and LI Guang-Di. 1999, Fusion Expression, Immunogenicity and Applications of C-terminally Truncated HCV Core Proteins. ''Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Acta Biochemica et Biophysica Sinica). ''31:''' '''61-66.
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| '''''Review'''''
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| 1.J. G. Forte and L. Zhu. 2010, Apical recycling of the gastric parietal cell H-K-ATPase, Annual Review of Physiology, 72: 21-44
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| = Abstracts (Presentations at International Conferences) =
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| # J. Suda, '''L. Zhu''', S. Karvar, May 2009, Intracellular localization and functional importance of Rab27b in gastric parietal cells, Digestive Disease Week 2009, Chicago, IL.
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| # '''L. Zhu''''', ''B. Zhang, J. Makdisi, J. Hatakeyama, C. Ender, J. Forte, December 2008, Chief cell specific expression of moesin in gastric glands, 48<sup>th</sup> Annual meeting of The American Society for Cell Biology, San Francisco, CA. abstract #346, board #B290.
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| # '''L. Zhu''', K. Poon, B. Zhang, M. Starr, C. Ender, J. Forte, December 2008, Phosphoisoforms of ezrin in gastric glands and proximal tubules, 48<sup>th</sup> Annual meeting of The American Society for Cell Biology, San Francisco, CA. abstract #347, board #B291.
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| # '''L. Zhu, '''J. Hatakeyama, A. Shastri, C. Chen, K. Poon, and J.G. Forte, April 2008, Different cell surface structures have different levels of ezrin phosphorylation, Experimental Biology Annual meeting 2008, San Diego, California, '''Oral presentation''' and poster presentation, abstract #5262
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| # '''L. Zhu''', R. Zhou, S. Mettler, T. Wu, A. Abbas, and J. G'''. '''Forte, April 2007, Reversible phosphorylation of ezrin T567: conformation, activity and physiology, Experimental Biology Annual meeting 2007, Washington D.C. FASEB J. 2007 21:760.5
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| # '''L. Zhu''', A. Abbas, T. Wu, S. Patel, S. Karvar, C.C. Yun, and J.G. Forte, December 2006, Phosphorylation of NHERF1/EBP50 in parietal cells, 46<sup>th</sup> Annual meeting of The American Society for Cell Biology, San Diego, CA. pg 58, abstract #416, board #B373.
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| # S. Karvar,''' L. Zhu, '''J. M. Crothers, and J. G. Forte, May 2006, Identification of Rab27b in gastric parietal cells, 107<sup>th</sup> annual meeting of the American gastroenterological association, Los Angeles, CA. ''Gastroenterology''. 130(4) (Suppl. 2): A-408. Abstract#: M2075.
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| # '''L. Zhu''', S. Karvar, J. Trinidad, V. Lao, J. Crothers, A. Burlingame, and J. Forte, August 2005, Modification of ATP synthase alpha is associated with stimulated acid secretion by gastric glands, Seventh international symposium on mass spectrometry in the health and life sciences, San Francisco, CA. ''Molecular & cellular proteomics''. 4(8)(Suppl. 2): S472.
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| # S. Karvar, '''L. Zhu''', W. Wong, J. M. Crothers, and J. G. Forte, May 2005, Differencial distribution dynamics of syntaxin-1 and syntaxin-3 in gastric parietal cells, 106<sup>th</sup> annual meeting of the American gastroenterological association, Chicago, IL. ''Gastroenterology.'' 128(4)(Suppl. 2):A-589. Abstract#: W1319.
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| # R. Zhou, A. Kodani, V. Li, '''L. Zhu''', J. Forte, December 2004, Phosphorylation of threonine-567 is not a functionally important site for apical membrane recruitment in parietal cells, 44<sup>th</sup> Annual meeting of The American Society for Cell Biology, Washington D.C. ''Molecular biology of the cell''. 15:171a, abstract # 950.
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| # '''L. Zhu'', '''''Y. Liu, J. G. Forte, December 2004, Ezrin oligomers are the membrane-bound dormant form in gastric parietal cells, 44<sup>th</sup> Annual meeting of The American Society for Cell Biology, Washington D.C. ''Molecular biology of the cell''. 15:171a, abstract # 948.
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| '''''Teaching experience: Mentoring undergraduate research'''''
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| # Lily Zhong, 2008-2009, Ezrin tyrosine phosphorylation in the gastric parietal cells.
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| # Hai Van Le, 2008-2009, Functional proteomic studies on gastric parietal cells.
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| # Cody Ender, 2008-2009, Identification of the activation factor for HK-ATPase.
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| # Michael Starr, 2008, (summer student from Harvey Mudd College, CA) EGF effect on ezrin tyrosine phosphorylation and gastric acid secretion.
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| # Bing Zhang, 2007-2009, Different expression pattern of ERM proteins in gastric gland.
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| # Joy Makdisi, 2007-2008, Identification of apical marker proteins in gastric parietal cells.
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| # Cheng Chen, 2007-2008, High turn-over of ezrin phosphorylation on T567.
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| # Jason Hatakeyama, 2007-2008, Identification of apical marker proteins in gastric parietal cells.
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| # Aditi Shastri, 2007-2008, Phosphorylation of ezrin in kidney proximal tubules: localization and activity.
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| # Kevin Poon, 2007-2008, Two dimensional electrophoresis of ezrin: comparative study between gastric glands and kidney proximal tubules.
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| # Aennes Abbas, 2006-2007, Expression of ezrin N-terminus in gastric parietal cell.
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| # Tim Wu, 2006-2007, Ezrin and NHERF1 in gastric glands.
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| # Joseph Delaney, 2005-2007, Ezrin binding proteins in gastric glands.
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| # Sajan Patel, 2005-2006, Two-dimensional electrophoresis of ezrin from gastric glands: protein phosphorylation upon stimulation of gastric glands.
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| # Veronica Lao, 2004-2005, Purification of ezrin from gastric glands.
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| # Vincent Li, 2003-2004, Construction and characterization of recombinant adenoviruses expressing ezrin.
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| # Ye Ye, 2000-2001, Development of a DNA vaccine against hepatitis C virus.
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| '''''Teaching experience: Mentoring MD fellows'''''
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| # Raza Patel, 2009-, Development of an animal model for non-alcoholic steatohepatitis and the use thereof.
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| = Teaching publication =
| | facility, including 58 separate research modules. Our laboratory, located on the fourth floor (Rooms 422 and 426) of the BRB, occupies approximately 1,250 sq. feet of space. |
| # '''Lixin Zhu''', 2008, Teaching glycoprotein with a classical paper: knowledge and methods in the course of an exciting discovery ---- The story of discovering HK-ATPase -subunit. Biochemistry and Molecular Biology Education. 36:336-340.
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| '''''Excellency in teaching laboratory courses'''''
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| | '''Our laboratory''' is well equipped for research endeavors involving molecular biology and cell biology (refrigerated high-speed and low-speed centrifuges, thermal cycler, -20C |
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| '''''Physiology'''''Perfusion of rabbit and mouse organs. Injection (ip, sc, iv) and bleeding of rabbit, rat and mouse.
| | and -80C freezers, vertical and horizontal electrophoresis apparatus, Western blot transfer apparatus, cell culture hood and incubators, regular and fluorescence plate readers). |
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| '''''Molecular biology'''''Recombinant DNA techniques. Construction of recombinant vaccinia virus and recombinant adenovirus.
| | There is also a large shared equipment work area equipped with multi-photon confocal microscope, upright and inverted fluorescence microscopes, FACS, real-time thermal |
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| '''''Biochemistry'''''Protein expression and purification, Western blotting, Immunoprecipitation, Protein-protein interaction by co-immunoprecipitation, GST pull-down and FRET.
| | cyclers, molecular imagers, nano-drop spectrometer, ultracentrifuges, gamma and beta counters, FPLC, HPLC and low temperature freezers. |
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| '''''Proteomics'''''2D-electrophoresis. Mass spectrometry. Phosphopeptide enrichment and identification.
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| '''''Cell Biology '''''Transient and stable transfections. Primary cell cultures. Cytotoxic T lymphocyte assay. Light and fluorescence microscopy. Confocal imaging (live and fixed cell). | | '''All research laboratories''' are located in close proximity on six floors(about 10 lab for each floor), which fosters continuing interaction, discussion and exchange of |
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| | information between staff, postdoctoral fellows, graduate students and technologists. |
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| '''''Societies'''''
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| | '''Our research interests span the broad areas of gastroenterology. Ongoing research projects include''': |
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| 1.The American Physiological Society, Gastrointestinal and Liver Section.
| | 1、 Pathogenesis of nonalcoholic steatohepatitis (NASH) |
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| 2.The American Society for Cell Biology.
| | 2、 Mechanism and regulation of gastric acid secretion |
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| 3.AAAS. The American Association for the Advancement of Science.
| | 3、 Using gastric parietal cell model to study general cell biology |
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| 4.The American Gastroenterological Association.
| | 4、 Pathogenesis of inflammatory bowel diseases (IBD) |
Lixin ZHU Ph.D.
Assistant Professor, Director, Research Laboratory, Digestive Disease and Nutrition Center,
Department of Pediatrics, State University of New York at Buffalo,
3435 Main Street, 422 BRB, Buffalo, NY14214
(716) 829-2191 (Office), (716) 829-2192 (Lab), (716) 829-3585 (Fax)
[lixinzhu@buffalo.edu] Faculty web page Lab web page
GI Research laboratory is located in the Biomedical Research Building (BRB) of the University at Buffalo - SUNY, South Campus, a relatively new, well equipped research
facility, including 58 separate research modules. Our laboratory, located on the fourth floor (Rooms 422 and 426) of the BRB, occupies approximately 1,250 sq. feet of space.
Our laboratory is well equipped for research endeavors involving molecular biology and cell biology (refrigerated high-speed and low-speed centrifuges, thermal cycler, -20C
and -80C freezers, vertical and horizontal electrophoresis apparatus, Western blot transfer apparatus, cell culture hood and incubators, regular and fluorescence plate readers).
There is also a large shared equipment work area equipped with multi-photon confocal microscope, upright and inverted fluorescence microscopes, FACS, real-time thermal
cyclers, molecular imagers, nano-drop spectrometer, ultracentrifuges, gamma and beta counters, FPLC, HPLC and low temperature freezers.
All research laboratories are located in close proximity on six floors(about 10 lab for each floor), which fosters continuing interaction, discussion and exchange of
information between staff, postdoctoral fellows, graduate students and technologists.
Our research interests span the broad areas of gastroenterology. Ongoing research projects include:
1、 Pathogenesis of nonalcoholic steatohepatitis (NASH)
2、 Mechanism and regulation of gastric acid secretion
3、 Using gastric parietal cell model to study general cell biology
4、 Pathogenesis of inflammatory bowel diseases (IBD)
Lixin ZHU Ph.D.
