Endy:Research

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Synthetic Biology)
Line 3: Line 3:
|-valign="top"
|-valign="top"
|style="background:#ffffff"|
|style="background:#ffffff"|
-
==Synthetic Biology==
+
==Genetic Memory==
The immediate goal of our research is to enable the engineering of genetically encoded memory systems.  Modest amounts of programmable memory, if implemented within living cells, would have a profound impact on the study and treatment of many diseases, and would broadly enable many non-medical applications of biotechnology.  We are interested in both the basic and applied aspects of the problem, from considering how to best store information inside cells, to practical applications.  Our overall long term goal is to help make biology easy to engineer, an area of research known as synthetic biology.
The immediate goal of our research is to enable the engineering of genetically encoded memory systems.  Modest amounts of programmable memory, if implemented within living cells, would have a profound impact on the study and treatment of many diseases, and would broadly enable many non-medical applications of biotechnology.  We are interested in both the basic and applied aspects of the problem, from considering how to best store information inside cells, to practical applications.  Our overall long term goal is to help make biology easy to engineer, an area of research known as synthetic biology.
-
 
-
==Postdocs==
 
-
*'''Jerome Bonnet''' (Stanford, October 2008 start)
 
-
**''[[Endy:Notebook/Genetic_Memory | Genetically Encoded Memory]],'' in progress
 
-
 
-
==PhD Students==
 
-
*'''Francois St-Pierre''' (MIT class of 200?)
 
-
**''Deterministic cell-fate selection during phage lambda infection'', or equivalent (in prep., Research Paper)
 
-
*'''Barry Canton''' (MIT class of 2008, TBA)
 
-
**''Engineering the interface between cellular chassis and synthetic biological systems'' ([URL pending, Dissertation])
 
-
**''BBa_F2620, an engineered cell-cell communication receiver device'' (in press, Research Paper)
 
-
**''A virtual machine for synthetic biology'', or equivalent (in prep., Research Paper)
 
-
*'''Jason Kelly''' (MIT class of 2008, TBA)
 
-
**''Tools and reference standards for evolving engineered biological systems'' ([URL pending, Dissertation])
 
-
**''Measurement kits and reference standards for characterizing BioBrick promoters and ribosome binding sites'', (submitted, Research Paper)
 
-
**''Programmed selection and preferential promotion of disadvantaged bacteria'', or equivalent (in prep., Research Paper)
 
-
*'''Reshma Shetty''' (MIT 2008 PhD, w/ Tom Knight as lead advisor, TBA)
 
-
**''Applying engineering principles to the design and construction of transcriptional devices'' ([http://dspace.mit.edu/handle/1721.1/41843 Dissertation])
 
-
**''Engineering BioBrick vectors from BioBrick parts'' ([http://www.jbioleng.org/content/2/1/5 Research Paper])
 
-
**''A synthetic biology approach to reprogramming bacterial odor'' (submitted, Research Paper)
 
-
**''Signal levels, load, and error rates in engineered transcriptional devices'', or equivalent (in prep., Research Paper)
 
-
*'''Samantha Sutton''' (MIT class of 2008 PhD, TBA)
 
-
**''Engineering phosphorylation-dependent post-translational protein devices'' ([URL pending, Dissertation])
 
-
**''Engineering phosphorylation-dependent post-translational protein devices'' (submitted, Research Paper)
 
-
**''Signals and specifications for a family of phosphorylation-dependent devices'', or equivalent (in prep., Research Paper)
 
-
*'''Ty Thomson''' (MIT class of 2008 PhD, moving to Epitome Biosystems)
 
-
**''Models and analysis of yeast mating response: Tools for model building, from documentation to time-dependent stimulation'' ([URL pending, Dissertation])
 
-
**''Tools for making systems biology models more scientific'' (in prep., Research Paper)
 
-
**''Mechanics, controls, and models of yeast mating response'' (in prep., Research Paper)
 
-
**''Measurement and analysis of protein abundances suggests tradeoff between signaling system output and dynamic range'' (in prep., Research Paper)
 
-
*'''Sri Kosuri''' (MIT class of 2007 PhD, now at a very low-profile biotechnology startup)
 
-
**''Simulation, models, and refactoring of bacteriophage T7 gene expression'' ([http://dspace.mit.edu/handle/1721.1/39912 Dissertation])
 
-
**''Refactoring bacteriophage T7'' ([http://www.nature.com/msb/journal/v1/n1/full/msb4100025.html Research Paper])
 
-
**''TABASCO: A single molecule, base-pair resolved gene expression simulator'' ([http://www.biomedcentral.com/1471-2105/8/480 Research Paper])
 
-
**''Measures and models of bacteriophage T7 gene expression'' (in prep., Research Paper)
 
-
 
-
==MS Students==
 
-
*'''Alex Mallet''' (MIT class of 2007, now at Microsoft, Inc.)
 
-
**''Analysis of Targeted and Combinatorial Approaches to Phage T7 Genome Generation'' ([http://dspace.mit.edu/handle/1721.1/35880 Thesis])
 
-
*'''Jeff Gritton''' (MIT class of 2006, now at Harvard Law School)
 
-
**''Architecture and evolutionary stability of yeast signaling pathways'' ([http://dspace.mit.edu/handle/1721.1/37258 Thesis])
 
-
 
-
==Undergraduate Students==
 
-
*'''iGEM 2008''' [http://openwetware.org/wiki/IGEM:MIT/2008 Project TBD] (MIT team's wiki)
 
-
*'''iGEM 2007''' [http://openwetware.org/wiki/IGEM:MIT/2007 Bioremediation] (MIT team's wiki)
 
-
*'''iGEM 2006''' [http://openwetware.org/wiki/IGEM:MIT/2006 Eau d'E. coli] (MIT team's wiki)
 
-
*'''iGEM 2005''' [http://openwetware.org/wiki/IGEM:MIT/2005 Biosensing] (MIT team's wiki)
 
-
*'''2004 Synthetic Biology Competition''', [http://images.google.com/images?hl=en&q=2004%20synthetic%20biology%20competition&um=1&ie=UTF-8&sa=N&tab=wi see Google] (web search)
 
-
*'''IAP 2004''' [http://parts.mit.edu/wiki/index.php/IAP2004:Polkadorks Polkadorks] (an "typical" project)
 
-
*'''IAP 2003''' [http://web.mit.edu/newsoffice/2003/blinkers-0226.html MIT News Report]
 

Revision as of 21:42, 7 September 2008

Home        Lab Members        Research        Notebooks        Publications        Internal        Contact       


Genetic Memory

The immediate goal of our research is to enable the engineering of genetically encoded memory systems. Modest amounts of programmable memory, if implemented within living cells, would have a profound impact on the study and treatment of many diseases, and would broadly enable many non-medical applications of biotechnology. We are interested in both the basic and applied aspects of the problem, from considering how to best store information inside cells, to practical applications. Our overall long term goal is to help make biology easy to engineer, an area of research known as synthetic biology.

Personal tools