Dunn:Projects - Revision history

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Fri, 11 Feb 2011 00:07:46 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 00:07, 11 February 2011
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	We are using techniques ranging from single-molecule assays to live cell imaging to test the hypothesis that mechanical force is an unrecognized regulator of extracellular matrix (ECM) remodeling. We are particularly interested in the possibility that mechanical force may increase the susceptibility of ECM proteins to proteolysis by matrix metalloproteinases, enzymes that are the subject of intense medical interest due to their roles in cancer metastasis. This idea has been difficult to test due to the challenge of visualizing ECM structure and mechanical forces at the cellular length scale. Novel instruments and assays developed in our research group allow us to explore the interplay of force and ECM remodeling for the first time.		We are using techniques ranging from single-molecule assays to live cell imaging to test the hypothesis that mechanical force is an unrecognized regulator of extracellular matrix (ECM) remodeling. We are particularly interested in the possibility that mechanical force may increase the susceptibility of ECM proteins to proteolysis by matrix metalloproteinases, enzymes that are the subject of intense medical interest due to their roles in cancer metastasis. This idea has been difficult to test due to the challenge of visualizing ECM structure and mechanical forces at the cellular length scale. Novel instruments and assays developed in our research group allow us to explore the interplay of force and ECM remodeling for the first time.

-	You can view ~~the~~ article [~~here]~~http://pubs.acs.org/articlesonrequest/AOR-ZrmMuD4JpNIG8SNzbjWU	+	You can view our recent article about that [http://pubs.acs.org/articlesonrequest/AOR-ZrmMuD4JpNIG8SNzbjWU\|'''here''']

	==<center>'''Understanding how myosin uses chemical energy to generate force and motion'''</center>==		==<center>'''Understanding how myosin uses chemical energy to generate force and motion'''</center>==

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Fri, 11 Feb 2011 00:04:57 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 00:04, 11 February 2011
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	We are using techniques ranging from single-molecule assays to live cell imaging to test the hypothesis that mechanical force is an unrecognized regulator of extracellular matrix (ECM) remodeling. We are particularly interested in the possibility that mechanical force may increase the susceptibility of ECM proteins to proteolysis by matrix metalloproteinases, enzymes that are the subject of intense medical interest due to their roles in cancer metastasis. This idea has been difficult to test due to the challenge of visualizing ECM structure and mechanical forces at the cellular length scale. Novel instruments and assays developed in our research group allow us to explore the interplay of force and ECM remodeling for the first time.		We are using techniques ranging from single-molecule assays to live cell imaging to test the hypothesis that mechanical force is an unrecognized regulator of extracellular matrix (ECM) remodeling. We are particularly interested in the possibility that mechanical force may increase the susceptibility of ECM proteins to proteolysis by matrix metalloproteinases, enzymes that are the subject of intense medical interest due to their roles in cancer metastasis. This idea has been difficult to test due to the challenge of visualizing ECM structure and mechanical forces at the cellular length scale. Novel instruments and assays developed in our research group allow us to explore the interplay of force and ECM remodeling for the first time.
		+
		+	You can view the article [here]http://pubs.acs.org/articlesonrequest/AOR-ZrmMuD4JpNIG8SNzbjWU

	==<center>'''Understanding how myosin uses chemical energy to generate force and motion'''</center>==		==<center>'''Understanding how myosin uses chemical energy to generate force and motion'''</center>==

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Fri, 11 Feb 2011 00:00:50 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 00:00, 11 February 2011
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	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]] [[Image:Collagen2.gif\|\|thumb\|150px\|~~center~~\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]]
		+
		+	[[Image:Collagen2.gif\|\|thumb\|150px\|right\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:59:20 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:59, 10 February 2011
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	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]] [[Image:Collagen2.gif\|\|thumb\|150px\|~~left~~\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]] [[Image:Collagen2.gif\|\|thumb\|150px\|center\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:58:11 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:58, 10 February 2011
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	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|150px\|left\|][Image:Collagen2.gif\|\|thumb\|150px\|left\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]] [[Image:Collagen2.gif\|\|thumb\|150px\|left\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:57:48 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:57, 10 February 2011
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	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|150px\|left\|Image:Collagen2.gif\|\|thumb\|150px\|left\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|][Image:Collagen2.gif\|\|thumb\|150px\|left\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:57:31 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:57, 10 February 2011
Line 3:		Line 3:
	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|Image:Collagen2.gif\|\|thumb\|150px\|left\|]]
-	[[Image:Collagen2.gif\|\|thumb\|150px\|left\|]]	+

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:57:01 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:57, 10 February 2011
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	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]]		[[Image:Collagen.gif\|\|thumb\|150px\|left\|]]
		+	[[Image:Collagen2.gif\|\|thumb\|150px\|left\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:55:11 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:55, 10 February 2011
Line 3:		Line 3:
	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|~~300px~~\|left\|]]	+	[[Image:Collagen.gif\|\|thumb\|150px\|left\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal

Maria Sorokina: /* Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling. */

Maria Sorokina — Thu, 10 Feb 2011 23:54:49 GMT

Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.

←Older revision		Revision as of 23:54, 10 February 2011
Line 3:		Line 3:
	==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==		==<center>'''Uncovering previously unrecognized functions of mechanical force in extracellular matrix remodeling.'''</center>==

-	[[Image:Collagen.gif\|\|thumb\|300px\|~~right~~\|]]	+	[[Image:Collagen.gif\|\|thumb\|300px\|left\|]]

	''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal		''The stiff, the hard, and the brittle are harbingers of death.'' – Tao Te Ching trans. Stan Rosenthal