Dionne: Difference between revisions
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Welcome to the Dionne lab! | ==Welcome to the Dionne lab!== | ||
We are interested in (1) the effects of host genetics on the biology of infection; and (2) the physiological control of metabolic balance. We use the fruitfly ''Drosophila melanogaster'' as a model | We are interested in (1) the effects of host genetics on the biology of infection; and (2) the physiological control of metabolic balance. | ||
==Host genetics and the biology of infection== | |||
Different individuals show different levels of resistance to specific infections and exhibit different pathogeneic effects after infection. We are interested in why this is the case. We use the fruitfly ''Drosophila melanogaster'' as a model host to study these questions; this allows us to screen for genes that affect the progress of infection in a rapid and unbiased fashion. | |||
All of our experiments originate from a simple genetic screen. Mutant flies are infected with ''Mycobacterium marinum'', a bacterium closely-related to the causative agent of tuberculosis, or with ''Mycobacterium smegmatis'', a related non-pathogen. We select lines of flies that die more quickly or more slowly than wild-type controls and determine the mutation that gives rise to this phenotype. We then try to understand what this phenotype tells us about the function of the mutated gene. | |||
==Physiological control of metabolic balance== | |||
==Recent updates to the lab wiki== | ==Recent updates to the lab wiki== | ||
<!--The line below includes a list of recent changes to your lab wiki on your homepage. If you've named your pages in the form <LabName>:Page name. Then you should just be able to replace the LabName below with your course's number and it should work.--> | <!--The line below includes a list of recent changes to your lab wiki on your homepage. If you've named your pages in the form <LabName>:Page name. Then you should just be able to replace the LabName below with your course's number and it should work.--> | ||
{{Special:Recentchanges/ | {{Special:Recentchanges/Dionne&limit=50}} | ||
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Revision as of 08:03, 3 May 2007
Welcome to the Dionne lab!
We are interested in (1) the effects of host genetics on the biology of infection; and (2) the physiological control of metabolic balance.
Host genetics and the biology of infection
Different individuals show different levels of resistance to specific infections and exhibit different pathogeneic effects after infection. We are interested in why this is the case. We use the fruitfly Drosophila melanogaster as a model host to study these questions; this allows us to screen for genes that affect the progress of infection in a rapid and unbiased fashion.
All of our experiments originate from a simple genetic screen. Mutant flies are infected with Mycobacterium marinum, a bacterium closely-related to the causative agent of tuberculosis, or with Mycobacterium smegmatis, a related non-pathogen. We select lines of flies that die more quickly or more slowly than wild-type controls and determine the mutation that gives rise to this phenotype. We then try to understand what this phenotype tells us about the function of the mutated gene.
Physiological control of metabolic balance
Recent updates to the lab wiki
List of abbreviations:
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26 April 2024
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08:43 (cur | prev) +16,816 Xning098 talk contribs (Created page with "{{Template:CHEM-ENG590E}} ==Introduction== Microfluidics is the science and technology of systems that process or manipulate small (10 <sup> -18 </sup> to 10 <sup>−18 </sup> litres) amounts of fluids, using channels with dimensions of tens to hundreds of micrometres, as stated by George Whitesides. <sup> https://doi.org/10.1038/nature05058 1 </sup>. Microfluidic devices are microchemical systems such as labs on the chip, organs on the chip and plants on the chip....") | |||
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