Diary: Difference between revisions
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We read in turn following two reviews of the structural DNA nanotechnology. | We read in turn following two reviews of the structural DNA nanotechnology. | ||
*Andre V. | *Andre V. Pinheiro, Dongran Han, William M. Shih, and Hao Yan ''Challenges and opportunities for structural DNA nanotechnology'' | ||
*Nadrian C. Seeman'' Nanomaterials Based on DNA'' | *Nadrian C. Seeman ''Nanomaterials Based on DNA'' | ||
[[24th]] | [[24th]] | ||
| Line 31: | Line 31: | ||
We read in turn following two papers. | We read in turn following two papers. | ||
*Qiao Jiang, | *Qiao Jiang, Chen Song, Jeanette Nangreave, Xiaowei Liu, Lin Lin, Dengli Qiu, Zhen-Gang Wang, Guozhang Zou, Xingjie Liang, Hao Yan, and Baoquan Ding ''DNA Origami as a Carrier for Circumvention of Drug Resistance'' | ||
The summary is as follows: | The summary is as follows: | ||
DNA origami as carrierThe DNA origami nanostructure, which is biocompatible and have spatially addressable surfaces for multi-functional activity, is presented as a promising drug carrier system in the treatment of cancer. It effectively loaded Doxorubicin, a well known anticancer drug, with itself and exhibited prominent citotoxity not only to regular human breast adenocarcinoma cancer cells (MCF 7), but more importantly to doxorubicin-resistant cancer cells. It seems that the inhibition of the lysosomal acidification, resulting in cellular redistribution of the drug to action sites contributes to that. | DNA origami as carrierThe DNA origami nanostructure, which is biocompatible and have spatially addressable surfaces for multi-functional activity, is presented as a promising drug carrier system in the treatment of cancer. It effectively loaded Doxorubicin, a well known anticancer drug, with itself and exhibited prominent citotoxity not only to regular human breast adenocarcinoma cancer cells (MCF 7), but more importantly to doxorubicin-resistant cancer cells. It seems that the inhibition of the lysosomal acidification, resulting in cellular redistribution of the drug to action sites contributes to that. | ||
[[8th]] | [[8th]] | ||
'''the fourth meeting''' | |||
We read in turn following two papers. | |||
*Martin Langecker, Vera Arnaut, Thomas G. Martin, Jonathan List, Stephan Renner, Michael Mayer, Hendrik Dietz, Friedrich C. Simmel ''Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures'' | |||
The summary is as follows: | |||
We created transmembrane channels in lipid bilayers by DNA origami. | |||
Single-channel electrophysiological experiments show that the synthetic channels have similarities to the natural ion channels such as conductances and channel gating. | |||
And single-molecule translocation experiments show that the synthetic channels can be used to discriminate single DNA molecules. | |||
[[15th]] | [[15th]] | ||
Revision as of 05:58, 25 June 2013
April
the first meeting
Team Todai nanORFEVRE was fixed as the name of our team. Yearly schedule was checked.
We read in turn following two reviews of the structural DNA nanotechnology.
- Andre V. Pinheiro, Dongran Han, William M. Shih, and Hao Yan Challenges and opportunities for structural DNA nanotechnology
- Nadrian C. Seeman Nanomaterials Based on DNA
the second meeting
We read two papers.
1.Folding DNA to create nanoscale shapes and patterns
- Paul W. K. Rothemund
Summary: A simple method for folding long, single-stranded DNA into arbitrary two-dimensional shapes was invented. The design for a desired shape is made by rater-filling the shape with scaffold and choosing staple strands to hold the scaffold in place. Once synthesized and mixed, the staple and scaffold strands self-assemble, and desired shapes such as squares and stars can be made.
May
the third meeting
We read in turn following two papers.
- Qiao Jiang, Chen Song, Jeanette Nangreave, Xiaowei Liu, Lin Lin, Dengli Qiu, Zhen-Gang Wang, Guozhang Zou, Xingjie Liang, Hao Yan, and Baoquan Ding DNA Origami as a Carrier for Circumvention of Drug Resistance
The summary is as follows: DNA origami as carrierThe DNA origami nanostructure, which is biocompatible and have spatially addressable surfaces for multi-functional activity, is presented as a promising drug carrier system in the treatment of cancer. It effectively loaded Doxorubicin, a well known anticancer drug, with itself and exhibited prominent citotoxity not only to regular human breast adenocarcinoma cancer cells (MCF 7), but more importantly to doxorubicin-resistant cancer cells. It seems that the inhibition of the lysosomal acidification, resulting in cellular redistribution of the drug to action sites contributes to that.
the fourth meeting
We read in turn following two papers.
- Martin Langecker, Vera Arnaut, Thomas G. Martin, Jonathan List, Stephan Renner, Michael Mayer, Hendrik Dietz, Friedrich C. Simmel Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
The summary is as follows: We created transmembrane channels in lipid bilayers by DNA origami. Single-channel electrophysiological experiments show that the synthetic channels have similarities to the natural ion channels such as conductances and channel gating. And single-molecule translocation experiments show that the synthetic channels can be used to discriminate single DNA molecules.
